Related Experiment Video

Updated: Jan 25, 2026

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC
11:38

High Content Screening Analysis to Evaluate the Toxicological Effects of Harmful and Potentially Harmful Constituents HPHC

Published on: May 10, 2016

12.7K

Toxicological and pharmacologic effects of farnesol (C15H26O): A descriptive systematic review

Gyllyandeson de Araújo Delmondes1, Daniel Souza Bezerra1, Diógenes de Queiroz Dias1

  • 1Regional University of Cariri (URCA), Crato, CE, Brazil.

Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association
|April 29, 2019
PubMed

Insights

This systematic review of farnesol (C15H26O) reveals diverse pharmacological and toxicological effects. Farnesol shows potential as an active or coadjuvant drug, with significant research into its antimicrobial and antitumor properties.

Area of Science:

  • Pharmacology
  • Toxicology
  • Natural Products Chemistry

Background:

  • Farnesol (C15H26O) is a natural acyclic sesquiterpene alcohol with documented biological activities.
  • Understanding its pharmacological and toxicological profile is crucial for therapeutic applications.

Purpose of the Study:

  • To systematically review preclinical and clinical studies on the pharmacological and toxicological effects of farnesol.
  • To consolidate existing research and identify key findings regarding farnesol's therapeutic potential.

Main Methods:

  • Systematic review conducted according to PRISMA guidelines.
  • Literature search across PubMed, MEDLINE, Scopus, and Web of Science databases.
  • Inclusion of English, Portuguese, and Spanish articles published between 1960 and 2017.

Main Results:

  • 76 articles were selected from 414 initial records.
  • Antimicrobial (51.32%) and antitumor (22.37%) effects were the most investigated areas.
  • Methodological biases were noted in both preclinical and clinical studies, particularly in group allocation and blinding.

Conclusions:

  • Farnesol exhibits varied pharmacological and toxicological characteristics.
  • The findings support farnesol's potential utility as an active pharmaceutical ingredient or a coadjuvant therapy.
  • Further high-quality research is warranted to address identified methodological limitations.
Keywords:
FarnesolPharmacological effectsSystematic reviewToxicological effects

More Related Videos

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors09:33

Imaging Approaches to Assessments of Toxicological Oxidative Stress Using Genetically-encoded Fluorogenic Sensors

Published on: February 7, 2018

7.9K
Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology10:26

Bladder Smooth Muscle Strip Contractility as a Method to Evaluate Lower Urinary Tract Pharmacology

Published on: August 18, 2014

26.9K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.3K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
10.9K
Pleural Disorders: Types and Brief Description01:30

Pleural Disorders: Types and Brief Description

The pleura is a vital part of the respiratory system. It's a double-layered membrane surrounding the lungs and lining the chest cavity. The two layers of the pleura are:
643
Eulerian and Lagrangian Flow Descriptions01:22

Eulerian and Lagrangian Flow Descriptions

Fluid flow analysis is critical in many scientific and engineering disciplines, and two principal approaches are used to describe this flow: the Eulerian and Lagrangian methods. These methods offer different perspectives on monitoring and analyzing the motion of fluids, each with distinct advantages depending on the scenario.
The Eulerian method focuses on fixed points in space where fluid properties, such as velocity, pressure, and temperature, are observed as the fluid moves between these...
1.9K
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
14.7K
Systematic Sampling Method01:17

Systematic Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
12.7K