Evolutionary dynamics of carbapenem-resistant Acinetobacter baumannii circulating in Chilean hospitals
Andrés Opazo-Capurro1, Iván San Martín2, Mario Quezada-Aguiluz2
1Laboratorio de Investigación en Agentes Antibacterianos (LIAA-UdeC), Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Chile; Millennium Nucleus for Collaborative Research on Bacterial Resistance (MICROB-R), Chile.
Abstract:
We analyze the evolutionary dynamics of ninety carbapenem-resistant Acinetobacter baumannii (CRAB) isolates collected between 1990 and 2015 in Chile. CRAB were identified at first in an isolate collected in 2005, which harbored the ISAba1-blaOXA-69 arrangement. Later, OXA-58- and OXA-23-producing A. baumannii strains emerged in 2007 and 2009, respectively. This phenomenon was associated with variations in the epidemiology of OXA-type carbapenemases, linked to nosocomial lineages belonging to ST109, ST162, ST15 (CC15) and ST318 (CC15).
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