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A Method to Study the Correlation Between Local Collagen Structure and Mechanical Properties of Atherosclerotic Plaque Fibrous Tissue
Published on: November 11, 2022
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Micromechanically-motivated analysis of fibrous tissue
M Ben-Or Frank1, J A Niestrawska2, G A Holzapfel3
1Department of Biomedical Engineering, Ben-Gurion University, Beer-Sheva, 84105, Israel.
Journal of the Mechanical Behavior of Biomedical Materials
|April 29, 2019
Summary
A new micromechanical model accurately predicts human aorta tissue mechanics using collagen fiber structure. This approach simplifies predicting fibrous tissue behavior, reducing experimental data needs.
Area of Science:
- Biomechanics
- Materials Science
- Biomedical Engineering
Background:
- Collagen fibers are critical load-bearing components in fibrous tissues.
- Accurate prediction of tissue mechanical response requires understanding collagen fiber structure and orientation.
- Developing predictive material models is essential for tissue engineering and medical device design.
Purpose of the Study:
- To develop and validate a micromechanical model for predicting the mechanical response of human aorta medial layer tissue.
- To correlate collagen fiber structural parameters with tissue mechanical behavior.
- To establish a simplified modeling approach for fibrous tissues.
Main Methods:
- Biaxial mechanical testing of human aorta medial layer tissue samples.
- Extraction of collagen fiber structural parameters from second-harmonic generation images.
- Development of a micromechanical model based on a six-layered laminate structure with periodic fibrous layers.
- Application of Hill-Mandel theory for periodic homogenization.
- Analytical and numerical model validation against experimental data.
Main Results:
- The developed micromechanical model accurately captures the mechanical response of aorta tissue samples up to 10% strain.
- The model predicts a near-linear response at lower strains and increasing stiffening at higher strains, particularly in the circumferential direction.
- Model predictions show good agreement with experimental data, especially when circumferential stretch dominates.
- Sensitivity analyses indicate minor effects of material model parameters and fiber dispersion on tissue response.
Conclusions:
- The micromechanical model provides a straightforward and effective method for predicting fibrous tissue mechanics.
- The approach reduces the necessity for extensive experimental data collection for mechanical behavior characterization.
- This modeling strategy holds potential for advancing the design and analysis of biomaterials and engineered tissues.
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