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Related Experiment Video

Updated: Jan 25, 2026

Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films

Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films

Published on: June 19, 2019

Crosstalk between chitosan and cell signaling pathways.

Behrouz Farhadihosseinabadi¹, Amir Zarebkohan^2,3, Mohamad Eftekhary¹

¹Department of Biotechnology, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Cellular and Molecular Life Sciences : CMLS

|April 29, 2019

Summary

This review explores chitosan (CS) interactions with cells in tissue engineering (TE). Understanding this cell-biomaterial crosstalk is key for advancing regenerative medicine and clinical applications of CS scaffolds.

Keywords:

Cancer Cell interaction Chitosan Immune system Intracellular signaling Molecular pathways Nerve system Regulation Stem cell

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Last Updated: Jan 25, 2026

Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films

Formation of Human Periodontal Ligament Cell Spheroids on Chitosan Films

Published on: June 19, 2019

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Preparation of Chitosan-based Injectable Hydrogels and Its Application in 3D Cell Culture

Published on: September 29, 2017

Area of Science:

Biomaterials Science
Tissue Engineering
Regenerative Medicine

Background:

Tissue engineering (TE) is rapidly advancing, with biomaterial scaffolds crucial for tissue regeneration.
Cell-biomaterial interactions significantly influence cell behavior, impacting TE success.
Chitosan (CS) is a widely used biomaterial in TE due to its favorable properties.

Purpose of the Study:

To review the crosstalk between chitosan and various cell types.
To elucidate the biological effects and mechanisms of chitosan on cellular activities.
To provide a roadmap for optimizing chitosan applications in TE and regenerative medicine.

Main Methods:

Literature review of studies on chitosan-cell interactions.
Analysis of reported biological effects of chitosan on cell differentiation, proliferation, and migration.
Synthesis of findings to understand chitosan's role in tissue regeneration.

Main Results:

Chitosan exhibits significant crosstalk with diverse cell types.
Its biocompatibility, antibacterial activity, and biodegradability are well-established.
Specific cellular responses to chitosan vary depending on cell type and material properties.

Conclusions:

Understanding chitosan-cell crosstalk is essential for effective TE applications.
This knowledge can guide the development of advanced chitosan-based scaffolds.
Optimized use of chitosan holds promise for future regenerative medicine strategies.