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Scanning Skeletal Remains for Bone Mineral Density in Forensic Contexts
Published on: January 29, 2018
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Association between bone mineral density and benign paroxysmal positional vertigo: a meta-analysis
Ling-Ling He1, Xin-Yi Li2, Miao-Miao Hou1
1Department of Neurology, Shanxi Dayi Hospital Affiliated to Shanxi Medical University, 99 Longcheng street, Taiyuan, Shanxi, China.
Summary
This meta-analysis found that patients with benign paroxysmal positional vertigo (BPPV) have significantly lower bone mineral density, indicating a higher risk of osteoporosis and osteopenia. These findings suggest low bone density may be a risk factor for BPPV.
Area of Science:
- Gerontology
- Neurology
- Orthopedics
Background:
- Conflicting conclusions exist regarding the association between bone mineral density (BMD) and benign paroxysmal positional vertigo (BPPV).
- Previous studies have investigated this link, necessitating a comprehensive evaluation.
Purpose of the Study:
- To evaluate the association between bone mineral density (BMD) and benign paroxysmal positional vertigo (BPPV).
- To determine if lower bone mineral density is a risk factor for BPPV.
Main Methods:
- A systematic literature search was conducted across major databases (PubMed, EMBASE, Cochrane Library, ScienceDirect, Web of Science) up to June 2018.
- Meta-analysis was performed using Statas14.0 software, calculating pooled odds ratios (OR) for osteoporosis/osteopenia incidence and standardized mean differences (SMD) for T scores.
- The study was registered with PROSPERO (CRD42018082271) to ensure transparency.
Main Results:
- Eleven studies involving 1982 subjects were included.
- BPPV patients showed a significantly higher incidence of osteoporosis and osteopenia combined (OR 3.27) compared to controls.
- Both osteoporosis (OR 3.48) and osteopenia (OR 1.75) incidences were higher in BPPV patients, who also had significantly lower T scores (SMD -0.82).
Conclusions:
- Patients with BPPV exhibit a higher risk of osteoporosis and osteopenia, alongside lower bone mineral density (T scores).
- These findings suggest that reduced bone mineral density may serve as a risk factor for developing BPPV.
- Further large-scale, multicenter studies are recommended to confirm these associations and explore precise risk factors.
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