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Alterations in ventral attention network connectivity in individuals with prediabetes
Jennifer R Sadler1, Grace E Shearrer1, Kyle S Burger1,2
1Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Nutritional Neuroscience
|April 30, 2019
Summary
Prediabetes alters brain connectivity, shifting focus from self-control to sensory networks. Healthy individuals show stronger connections between self-control and attention networks, unlike those with prediabetes.
Area of Science:
- Neuroscience
- Endocrinology
- Metabolic Disorders
Background:
- Type 2 diabetes (T2D) is linked to abnormal brain function, but the exact timing of these changes during T2D progression remains unclear.
- Understanding neural alterations in prediabetes is crucial for early intervention strategies.
- Functional connectivity differences may indicate early brain changes preceding T2D diagnosis.
Purpose of the Study:
- To investigate functional brain connectivity differences in adults with prediabetes compared to healthy individuals.
- To determine if prediabetes, defined by glycated hemoglobin (HbA1c) levels, is associated with disruptions in the default mode network (DMN).
- To explore alterations in connectivity between various brain networks in prediabetes.
Main Methods:
- Functional connectivity was assessed in 88 adults (44 prediabetes, 44 healthy), matched for sex, age, and BMI.
- Fourteen distinct brain networks were analyzed, with a specific focus on the DMN.
- HbA1c levels were used to define prediabetes (5.7-6.4%) and healthy controls (≤5.7%).
Main Results:
- No significant differences in DMN connectivity were observed between prediabetes and healthy groups.
- Individuals with prediabetes exhibited stronger connectivity between the ventral attention network and visual/somatosensory networks.
- Healthy individuals showed stronger ventral attention network connectivity with the cingulo-opercular and thalamic-striatal-visual networks.
Conclusions:
- Prediabetes is characterized by a shift in functional connectivity, with increased links between sensory and attention networks.
- Healthy individuals demonstrate enhanced connectivity between self-control and attention networks compared to those with prediabetes.
- While T2D is associated with decreased DMN connectivity, prediabetes shows a distinct pattern of altered functional connectivity.
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