Testing Models of Human Declarative Memory at the Single-Neuron Level

Deciphering the mechanisms of declarative memory is a major goal of neuroscience. While much theoretical progress has been made, it has proven difficult to experimentally verify key predictions of some foundational models of memory. Recently, single-neuron recordings in human patients have started to provide direct experimental verification of some theories, including mnemonic evidence accumulation, balance-of-evidence for confidence judgments, sparse coding, contextual reinstatement, and the ventral tegmental area (VTA)-hippocampus loop model. Here, we summarize the cell types that have been described in the medial temporal lobe and posterior parietal cortex, discuss their properties, and reflect on how these findings inform theoretical work. This body of work exemplifies the scientific power of a synergistic combination of modeling and human single-neuron recordings to advance cognitive neuroscience.