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Updated: Jan 25, 2026

High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment
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High-resolution Melting PCR for Complement Receptor 1 Length Polymorphism Genotyping: An Innovative Tool for Alzheimer's Disease Gene Susceptibility Assessment

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Complement factor H gene polymorphisms and vivax malaria associated thrombotic microangiopathy

Parimal Agrawal1, Ashwani Kumar1, Amber Parwaiz1

  • 1Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.

Saudi Journal of Kidney Diseases and Transplantation : an Official Publication of the Saudi Center for Organ Transplantation, Saudi Arabia
|April 30, 2019
PubMed

Insights

Malaria can cause acute kidney injury (AKI), and this rare complication, thrombotic microangiopathy (TMA), is linked to complement dysregulation. This case highlights genetic variants in complement factor H (CFH) predisposing to TMA in malaria.

Area of Science:

  • Nephrology
  • Immunology
  • Genetics

Background:

  • Acute kidney injury (AKI) affects approximately 1% of malaria cases, with a high mortality rate of up to 45%.
  • Thrombotic microangiopathy (TMA) is a rare but severe cause of AKI in malaria patients.
  • Dysregulation of the alternate complement pathway (ACP) is a known mechanism in TMA development.

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