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Altered Local and Large-Scale Dynamic Functional Connectivity Variability in Posttraumatic Stress Disorder: A
Shishun Fu1,2, Xiaofen Ma2, Yunfan Wu2
1The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China.
Frontiers in Psychiatry
|April 30, 2019
Summary
Posttraumatic stress disorder (PTSD) is linked to altered brain connectivity patterns. This study reveals dynamic changes in functional connectivity within and between brain networks in PTSD patients, offering new insights into the condition.
Area of Science:
- Neuroscience
- Psychiatry
- Medical Imaging
Background:
- Posttraumatic stress disorder (PTSD) is a psychiatric condition following trauma.
- Previous studies show altered resting-state functional connectivity (FC) in PTSD.
- Dynamic changes in FC over time in PTSD remain under-explored.
Purpose of the Study:
- To investigate dynamic changes in resting-state local and large-scale functional connectivity (FC) in PTSD patients compared to healthy controls.
- To examine the relationship between PTSD symptom severity and dynamic FC.
- To identify specific brain networks and regions exhibiting altered dynamic FC patterns.
Main Methods:
- Compared dynamic resting-state FC using sliding window analysis in PTSD patients (n=22) and healthy controls (HC; n=22).
- Assessed local dynamic FC via dynamic regional homogeneity (dReHo).
- Investigated large-scale dynamic FC (dFC) between regions with significant dReHo differences and correlated with symptom severity.
Main Results:
- PTSD patients exhibited increased dReHo variability in the left precuneus (PCu).
- Increased dynamic FC was observed between the left PCu and left insula in PTSD.
- Decreased dFC was found between the left PCu and left inferior parietal lobe (IPL), and between left and right PCu in PTSD patients.
Conclusions:
- PTSD is characterized by aberrant, fluctuating communication patterns within the default mode network (DMN) and between the salience network and DMN.
- Dynamic FC alterations in specific brain regions like the precuneus and insula are implicated in PTSD.
- No significant correlation was found between clinical indicators and dynamic FC/dReHo after correction, suggesting complex underlying mechanisms.
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