Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

9.9K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
9.9K
Humoral Immune Responses01:36

Humoral Immune Responses

83.5K
Overview
83.5K
Complementation Tests00:49

Complementation Tests

6.1K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.1K
What are Biogeochemical Cycles?00:54

What are Biogeochemical Cycles?

39.2K
The most common elements in organic molecules, carbon, hydrogen, oxygen, nitrogen, sulfur, and phosphorus, are only available in the ecosystem in limited amounts. Therefore, these nutrients must be recycled through both biotic and abiotic components of the ecosystem, in processes generally called biogeochemical cycles.
39.2K
The Water Cycle01:00

The Water Cycle

28.2K
The Earth’s hydrosphere includes all of the areas where the storage and movement of water occurs. Since water is the basis of all living processes, the cycling of water is extremely important to ecosystem dynamics.
28.2K
What is the Immune System?01:38

What is the Immune System?

127.2K
Overview
127.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lack of IL-1R8 in neurons causes hyperactivation of IL-1 receptor pathway and induces MECP2-dependent synaptic defects.

eLife·2017
Same author

Intraperitoneal adoptive transfer of mesenchymal stem cells enhances recovery from acid aspiration acute lung injury in mice.

Intensive care medicine experimental·2017
Same author

Driver mutations (JAK2V617F, MPLW515L/K or CALR), pentraxin-3 and C-reactive protein in essential thrombocythemia and polycythemia vera.

Journal of hematology & oncology·2017
Same author

Analysis of Food Safety and Security Challenges in Emerging African Food Producing Areas through a One Health Lens: The Dairy Chains in Mali.

Journal of food protection·2017
Same author

The Hotspot for (Global) One Health in Primary Food Production: Aflatoxin M1 in Dairy Products.

Frontiers in public health·2017
Same author

Interleukin 37 reverses the metabolic cost of inflammation, increases oxidative respiration, and improves exercise tolerance.

Proceedings of the National Academy of Sciences of the United States of America·2017
Same journal

Research advances and application prospects of CAR-T therapy in the treatment of age-related diseases.

Frontiers in immunology·2026
Same journal

Machine learning-driven identification and immunohistochemical validation of an integrated immune-inflammatory phenotype for disease-free survival stratification in breast cancer.

Frontiers in immunology·2026
Same journal

Modified treatment protocol for pediatric systemic lupus erythematosus-associated hemophagocytic lymphohistiocytosis with central nervous system involvement: a case report.

Frontiers in immunology·2026
Same journal

Exploratory characterization of IgG1/IgG4 glycosylation and monocyte-derived dendritic cell responses in esophageal squamous cell carcinoma.

Frontiers in immunology·2026
Same journal

JAK-STAT pathway-associated skin diseases: a refined functional framework for inflammatory skin diseases.

Frontiers in immunology·2026
Same journal

Cross-talk among novel programmed cell death pathways: a decisive network in renal ischemia-reperfusion injury.

Frontiers in immunology·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

2.0K

Complementing the Cancer-Immunity Cycle.

Ruben Pio1,2,3, Daniel Ajona1,2,3, Sergio Ortiz-Espinosa1

  • 1Program in Solid Tumors (CIMA) and Department of Biochemistry and Genetics (School of Medicine), University of Navarra, Pamplona, Spain.

Frontiers in Immunology
|April 30, 2019
PubMed
Summary
This summary is machine-generated.

The complement system can hinder anti-cancer immunity by promoting immunosuppressive cells. Blocking complement may enhance the effectiveness of immune checkpoint inhibitors like anti-PD-1/PD-L1 therapies.

Keywords:
C1qC3aC5aPD-1PD-L1cancer immunitycomplement systemimmunotherapy

More Related Videos

Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K
Use of the Pyrimidine Analog, 5-Iodo-2′-Deoxyuridine IdU with Cell Cycle Markers to Establish Cell Cycle Phases in a Mass Cytometry Platform
08:37

Use of the Pyrimidine Analog, 5-Iodo-2′-Deoxyuridine IdU with Cell Cycle Markers to Establish Cell Cycle Phases in a Mass Cytometry Platform

Published on: October 22, 2021

3.4K

Related Experiment Videos

Last Updated: Jan 25, 2026

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
12:19

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics

Published on: June 7, 2024

2.0K
Depletion of Specific Cell Populations by Complement Depletion
06:17

Depletion of Specific Cell Populations by Complement Depletion

Published on: February 5, 2010

22.7K
Use of the Pyrimidine Analog, 5-Iodo-2′-Deoxyuridine IdU with Cell Cycle Markers to Establish Cell Cycle Phases in a Mass Cytometry Platform
08:37

Use of the Pyrimidine Analog, 5-Iodo-2′-Deoxyuridine IdU with Cell Cycle Markers to Establish Cell Cycle Phases in a Mass Cytometry Platform

Published on: October 22, 2021

3.4K

Area of Science:

  • Immunology
  • Oncology
  • Innate Immunity

Background:

  • Cancer immunotherapy has advanced with immune checkpoint inhibitors targeting PD-1/PD-L1, improving outcomes for melanoma and lung cancer.
  • However, many patients do not respond to these therapies, highlighting the need for combination strategies.
  • Understanding the complex interactions within the cancer-immune cycle is crucial for developing effective treatments.

Purpose of the Study:

  • This review examines the role of the complement system in the cancer-immunity cycle.
  • It focuses on how complement components influence antitumor immune responses.
  • The goal is to identify therapeutic targets within the complement system to enhance current immunotherapies.

Main Methods:

  • Review of existing literature on the complement system and cancer immunity.
  • Analysis of the functions of specific complement components (C1q, C3a, C5a) and their receptors (C3aR, C5aR1).
  • Evaluation of evidence linking complement to immunosuppressive cell recruitment and activation.

Main Results:

  • The complement system acts as a key regulator of cancer immunity, often promoting immune suppression.
  • Complement effectors like C3a and C5a can induce tolerogenic cell death and inhibit T-cell responses.
  • These components facilitate the recruitment and activation of immunosuppressive cells, including MDSCs, Tregs, and M2 TAMs.

Conclusions:

  • The complement system actively blocks anti-tumor immune responses within the cancer-immunity cycle.
  • Targeting complement pathways offers a promising strategy to overcome resistance to anti-PD-1/PD-L1 therapies.
  • Combination therapies involving complement inhibitors and checkpoint blockade could significantly improve cancer treatment efficacy.