Prevalence of non-acute ischaemic cardiomyopathy in a Pakistani cohort

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Muhammad Salman Ghazni1, Saba Aijaz1, Rehan Malik1

  • 1Cardiology, Tabba Heart Institute, Karachi, Pakistan.

Heart Asia
|April 30, 2019
PubMed

Insights

Nearly half of heart failure patients with reduced ejection fraction have obstructive coronary artery disease. Early detection through clinical history and non-invasive testing aids in identifying these patients for timely intervention.

Area of Science:

  • Cardiology
  • Internal Medicine

Background:

  • Heart failure with reduced left ventricular ejection fraction (HFrEF) is a common clinical condition.
  • Coronary angiography (CAG) is used to identify obstructive epicardial coronary artery disease (CAD) as a cause of HFrEF.

Purpose of the Study:

  • To determine the frequency of obstructive CAD (OCAD) in HFrEF patients.
  • To identify independent predictors of OCAD.
  • To analyze the outcomes associated with OCAD.

Main Methods:

  • Retrospective observational study of patients undergoing CAG.
  • Exclusion of patients with prior known CAD or revascularization.
  • Regression modeling to identify OCAD predictors and log-rank test for survival comparison.

Main Results:

  • Out of 260 HFrEF patients, 119 (45.8%) had OCAD.
  • Predictors included age >50, chest pain, family history of premature CAD, and prior non-invasive stress testing.
  • Survival was significantly lower in OCAD patients without revascularization.

Conclusions:

  • OCAD is prevalent in nearly half of HFrEF patients undergoing CAG.
  • Clinical assessment and non-invasive stress testing improve patient selection for CAG.

Keywords:
coronary angiographyischaemic cardiomyopathysystolic heart failure

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