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Nine contemporary therapeutic directions in heart failure

Zaid Almarzooq1, Manan Pareek1,2, Lauren Sinnenberg1

  • 1Brigham and Women's Hospital Heart and Vascular Center and Harvard Medical School, Boston, Massachusetts, USA.

Heart Asia
|April 30, 2019
PubMed

Insights

Recent advances in heart failure management, especially for heart failure with reduced ejection fraction, offer new therapeutic options. Key areas include novel drug classes and devices improving patient outcomes and addressing sudden cardiac death.

Area of Science:

  • Cardiology
  • Heart Failure Research
  • Therapeutic Advances

Background:

  • Global heart failure burden is increasing, affecting 26 million people with significant health expenditures.
  • Recent scientific progress has significantly impacted heart failure management, particularly for heart failure with reduced ejection fraction.
  • This review focuses on nine key therapeutic areas influenced by these advancements.

Purpose of the Study:

  • To discuss recent scientific progress in heart failure.
  • To highlight nine distinct therapeutic areas significantly influenced by these advances.
  • To provide an overview of emerging and established treatments in heart failure.

Main Methods:

  • Review of recent practice-influencing studies in heart failure.
  • Discussion of advancements across nine distinct therapeutic areas.
  • Synthesis of current evidence and clinical considerations.

Main Results:

  • Emergence of sodium-glucose cotransporter-2 inhibitors as a new therapeutic class.
  • Broadened application of angiotensin-neprilysin inhibition.
  • Considerations for therapy withdrawal in recovered heart failure patients.
  • Benefits of low-dose direct oral anticoagulants in sinus rhythm.
  • Targeted therapy for cardiac amyloidosis.
  • Usefulness of mitral valve repair for heart failure.
  • Advent of newer left ventricular assist devices for advanced heart failure.
  • Role of ablation in atrial fibrillation in heart failure patients.
  • Use of wearable defibrillators for sudden death prevention.

Conclusions:

  • Significant therapeutic progress has been made in heart failure management.
  • Multiple frontiers in heart failure treatment have been advanced.
  • These advancements offer improved strategies for diverse patient populations and conditions.

Keywords:
heart failureheart failure treatmentleft ventricular assist device

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