The efficacy of immune checkpoint inhibitors in advanced non-small cell lung cancer harboring driver mutations

Hiroaki Sakamoto1, Hisashi Tanaka1, Toshihiro Shiratori1

  • 1Department of Respiratory Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Aomori 036-8562, Japan.

Insights

Immune checkpoint inhibitors (ICIs) show some efficacy in advanced non-small cell lung cancer (NSCLC) with driver mutations. Prior tyrosine kinase inhibitor (TKI) duration may influence ICI treatment outcomes.

Area of Science:

  • Oncology
  • Immunotherapy
  • Genetics

Background:

  • Advanced non-small cell lung cancer (NSCLC) often harbors driver mutations.
  • Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment.
  • The efficacy of ICIs in NSCLC patients with driver mutations requires further investigation.

Purpose of the Study:

  • To evaluate the efficacy of ICIs (nivolumab, pembrolizumab) in advanced NSCLC patients with driver mutations.
  • To explore factors influencing ICI treatment outcomes in this patient population.

Main Methods:

  • Retrospective study of 24 NSCLC patients with driver mutations treated with ICIs.
  • Analysis of patient characteristics, overall response rate (ORR), disease control rate (DCR), and progression-free survival (PFS).
  • Comparison of PFS based on prior tyrosine kinase inhibitor (TKI) treatment duration.

Main Results:

  • ORR was 16.7% (95% CI, 7.0-37.1%) and DCR was 33.4% (95% CI, 18.9-55.1%).
  • Median PFS was 62 days (95% CI 52-81 days).
  • Patients treated with TKIs for >1 year had longer PFS (110 days) compared to those treated for <1 year (56 days, P=0.012).

Conclusions:

  • Some NSCLC patients with driver mutations may benefit from ICIs.
  • Duration of prior TKI therapy appears to be associated with ICI treatment efficacy.

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