Do clinicopathologic features of rectal and colon cancer guide us towards distinct malignancies?

Unlike developed countries where studies on all aspects of colorectal cancers are widely numerous, Iran as a Middle Eastern country show very few studies especially ones comparing the differences between colon and rectal cancer. In this study, firstly we report demographic, clinical and pathologic characteristics of patients with rectum and colon cancer and secondly compare these findings in order to investigate probable differences.

In this cross-sectional study, 238 patients were divided into two groups: the rectal cancer group and the colonic cancer group. Demographic, clinical and pathologic information of patients were statistically compared using Stata version 12.

There were no statistical differences between the two groups regarding age and gender and BMI. Regarding clinical presentation, the proportion of rectal bleeding was significantly higher in colon cancer group (P<0.001). Moreover, abdominal pain was significantly more frequent in colon cancer group (P<0.001). Tumor stage showed statistically difference between the two groups (P=0.02).

We did not find enough evidences to conclude that rectal cancer and colon cancer should be investigated as two distinct malignancies but findings showed significant differences such as stage at diagnosis encouraged us in order to conduct other appropriate studies for better evaluation of this issue.