Related Experiment Video
Updated: Jan 25, 2026

High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
Published on: August 11, 2014
Endocarditis following Consumption of Cereal Associated with Salmonella enterica Subtype Mbandaka Outbreak
Jana K Dickter1, LiYing Cai2, David S Snyder3
1City of Hope, Division of Infectious Diseases, Duarte, CA, USA.
Abstract:
A 69-year-old immunocompromised man developed mitral valve endocarditis due to Salmonella enterica serotype Mbandaka, contracted from the cereal outbreak. The patient had a history of HLA-matched related hematopoietic stem cell transplant with persistent graft-versus-host disease (GVHD). This case report discusses prior international outbreaks that occurred due to Salmonella enterica subtype Mbandaka, the risks of developing endovascular infections from salmonellosis, and persistent infections that may develop more frequently with S. enterica serotype Mbandaka. The patient received a six-week course of intravenous antibiotics and remains on oral suppressive antibiotics, with his length of therapy to be determined based on his GVHD treatment.
Insights
A rare case of mitral valve endocarditis caused by Salmonella Mbandaka occurred in an immunocompromised patient following a cereal outbreak. This highlights the risk of severe Salmonella infections, particularly in transplant recipients with graft-versus-host disease.
Area of Science:
- Infectious Diseases
- Cardiology
- Immunology
Background:
- Salmonella enterica serotype Mbandaka outbreaks have been linked to contaminated food products, posing public health risks.
- Immunocompromised individuals, especially those with a history of hematopoietic stem cell transplant and graft-versus-host disease (GVHD), are at increased risk for severe infections.
- Endocarditis, an infection of the heart's inner lining, can be a serious complication of salmonellosis.
More Related Videos
12:18An Allelotyping PCR for Identifying Salmonella enterica serovars Enteritidis, Hadar, Heidelberg, and Typhimurium
Published on: July 22, 2011
08:24Loop-Mediated Isothermal Amplification for Screening Salmonella in Animal Food and Confirming Salmonella from Culture Isolation
Published on: May 20, 2020
Related Concept Videos
Endocarditis II: Clinical Features of Infective Endocarditis
Endocarditis I: Introduction
Steps in Outbreak Investigation
Adrenergic Receptors: ɑ Subtype
Adrenaline ≥ Noradrenaline >> Isoprenaline
α-adrenoceptors are further divided into α1 and α2-adrenoceptors.
α1-Adrenoceptors: These receptors are located postsynaptically on the effector organs and cause constriction of smooth muscle mediated by activation of phospholipase...
Adrenergic Receptors: β Subtype
Isoprenaline > Adrenaline > Noradrenaline
Neurotransmitter binding to these receptors causes activation of adenylyl cyclase resulting in increased concentrations of cAMP and modulation of calcium ion channels within the cell. They are further classified into β1, β2, and β3 subtypes.
β1-adrenoceptors: β1-adrenoceptors...
Diabetes Mellitus: Overview and Type I Subtype
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...