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Related Concept Videos

Adult Stem Cells01:33

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Embryonic Stem Cells00:57

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Stem cells are undifferentiated cells that divide and produce different types of cells. Ordinarily, cells that have differentiated into a specific cell type are post-mitotic—that is, they no longer divide. However, scientists have found a way to reprogram these mature cells so that they “de-differentiate” and return to an unspecialized, proliferative state. These cells are also pluripotent like embryonic stem cells—able to produce all cell types—and are therefore...
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Some individuals interpret life events as a consequence of their personal choices and actions, while others believe that outcomes are dictated by fate or destiny. This divergence in perspective has been examined in psychological and cross-cultural studies, particularly in relation to religious faith and cultural beliefs about causality.Fate and Personal ResponsibilityPeople who emphasize personal responsibility view events as direct consequences of their decisions. For instance, breaking a leg...
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Fate Mapping of Human Embryonic Stem Cells by Teratoma Formation
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Functional endoscopy techniques for tracking stem cell fate.

Yusi Miao1, Zhongping Chen1, Shengwen Calvin Li2,3,4

  • 1Beckman Laser Institute, University of California Irvine, Irvine, CA, USA.

Quantitative Imaging in Medicine and Surgery
|April 30, 2019
PubMed
Summary
This summary is machine-generated.

Tracking implanted stem cells is crucial for effective stem cell therapy. This study reviews advanced endoscopic imaging techniques for precise, real-time monitoring of stem cell behavior in vivo.

Keywords:
Endoscopybiological GPScell trackingstem cell research

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Area of Science:

  • Regenerative Medicine
  • Biomedical Imaging
  • Molecular Imaging

Background:

  • Accurate tracking of implanted stem cells is vital for optimizing stem cell therapy outcomes and patient safety in precision medicine.
  • Existing methods like MRI, PET, and optical imaging have limitations in high-resolution, real-time, internal monitoring.
  • The biological Global Positioning System (bGPS) concept aims to provide comprehensive in vivo stem cell tracking.

Purpose of the Study:

  • To review recent advancements in functional endoscopic imaging techniques for stem cell monitoring.
  • To highlight the application of optical-based imaging modalities for in vivo stem cell tracking.
  • To provide future perspectives on developing endoscopic molecular imaging for single-cell level analysis.

Main Methods:

  • Review of existing literature on various imaging modalities for stem cell tracking.
  • Focus on optical-based functional imaging techniques: photoacoustic imaging (PAI), optical coherence tomography (OCT), and multiphoton microscopy (MPM).
  • Discussion of miniaturized endoscopic probes utilizing optical fibers for high-resolution imaging.

Main Results:

  • Optical-based functional imaging, integrated into small endoscopes, enables high-resolution cellular imaging within the body.
  • Endoscopic techniques offer advantages for miniaturization and maintaining imaging quality for in vivo stem cell visualization.
  • Progress has been made in designing reporter genes and molecular probes for enhanced imaging.

Conclusions:

  • Functional endoscopy represents a promising frontier for in vivo stem cell monitoring.
  • These techniques facilitate detailed tracking of stem cell biodistribution and behavior.
  • Future developments in endoscopic molecular imaging will enable precise monitoring of subclonal evolution at the single-cell level.