Related Experiment Video
Updated: Jan 25, 2026
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Cutaneous Surgical Denervation: A Method for Testing the Requirement for Nerves in Mouse Models of Skin Disease
Published on: June 26, 2016
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Skin Directed Therapy in Cutaneous T-Cell Lymphoma
Erica S Tarabadkar1, Michi M Shinohara1
1Division of Dermatology, University of Washington, Seattle, WA, United States.
Frontiers in Oncology
|April 30, 2019
Summary
Skin directed therapies (SDTs) are crucial for treating cutaneous T-cell lymphoma (CTCL)/mycosis fungoides (MF). Topical treatments, phototherapy, and radiation therapy offer effective management options for all stages of MF, improving patient quality of life.
Area of Science:
- Dermatology
- Oncology
Background:
- Cutaneous T-cell lymphoma (CTCL), also known as mycosis fungoides (MF), is a type of non-Hodgkin lymphoma affecting the skin.
- Skin-directed therapies (SDTs) are vital for managing MF at all disease stages.
Purpose of the Study:
- To review the current landscape of SDTs for CTCL/MF.
- To highlight the efficacy and safety of various topical, phototherapy, and radiation-based treatment modalities.
Main Methods:
- Review of existing literature on SDTs for CTCL/MF.
- Analysis of response rates, efficacy, and safety data for different treatment types.
Main Results:
- Numerous topical therapies show high response rates, especially in early-stage MF.
- Phototherapy (UVB, PUVA) demonstrates efficacy and long-term safety.
- Radiation therapy remains a cornerstone treatment for all MF stages.
Conclusions:
- SDTs are essential for treating CTCL/MF, managing symptoms, and enhancing quality of life.
- A variety of effective SDT options are available for MF patients.
- Continued research supports the role of phototherapy and radiation in MF management.
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