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Inducing Myointimal Hyperplasia Versus Atherosclerosis in Mice: An Introduction of Two Valid Models
Published on: May 14, 2014
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Mouse Models for Atherosclerosis Research-Which Is My Line?
Sara Oppi1, Thomas F Lüscher1,2, Sokrates Stein1
1Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.
Frontiers in Cardiovascular Medicine
|April 30, 2019
Summary
Choosing the right mouse model is crucial for studying atherosclerosis, a complex immunometabolic disease. This guide helps researchers select appropriate models for investigating cardiovascular disease progression and inter-organ crosstalk.
Area of Science:
- Immunometabolism
- Cardiovascular Science
- Animal Models
Background:
- Atherosclerosis is a chronic, progressive immunometabolic disease and a leading cause of cardiovascular mortality.
- Studying atherosclerosis in humans is challenging due to its decades-long evolution, necessitating the use of animal models.
- Genetically modified mouse models are frequently employed to study atherogenic processes and inter-organ crosstalk in a compressed timeframe.
Purpose of the Study:
- To provide a comprehensive overview of existing and novel genetically modified mouse models for atherosclerosis research.
- To highlight the critical differences among mouse models regarding metabolism, reverse cholesterol transport, obesity, diabetes, and inflammation.
- To offer a roadmap to assist researchers in selecting the most suitable mouse model based on their specific scientific objectives.
Main Methods:
- Review and comparison of various genetically modified mouse models used in atherosclerosis research.
- Analysis of key physiological and pathological differences impacting disease development and progression.
- Synthesis of information to create a decision-making framework for model selection.
Main Results:
- Mouse models exhibit significant variations in cholesterol metabolism, lipoprotein profiles, and inflammatory responses, influencing atherosclerosis development.
- Different models recapitulate distinct facets of atherosclerosis, including obesity, diabetes, and reverse cholesterol transport.
- The choice of mouse model directly impacts the study of specific atherogenic processes and inter-organ communication.
Conclusions:
- The selection of an appropriate mouse model is paramount for the successful investigation of atherosclerosis's multifaceted nature.
- Understanding the distinct characteristics of each model is essential for generating reliable and relevant research findings.
- This work provides a valuable resource for researchers aiming to advance the study of atherosclerosis and its associated cardiovascular diseases.
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