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In Silico Integration Approach Reveals Key MicroRNAs and Their Target Genes in Follicular Thyroid Carcinoma

Shengqing Hu1, Yunfei Liao1, Juan Zheng1

  • 1Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China.

Biomed Research International
|April 30, 2019
PubMed

Insights

This study identifies key microRNAs (miRNAs) and their target genes involved in follicular thyroid carcinoma (FTC) pathogenesis. The findings offer molecular insights for diagnosing and treating FTC.

Area of Science:

  • Oncology
  • Molecular Biology
  • Bioinformatics

Background:

  • Follicular thyroid carcinoma (FTC) pathogenesis requires deeper molecular understanding.
  • Identifying key regulatory molecules like microRNAs (miRNAs) and their gene targets is crucial for diagnosis and treatment.

Purpose of the Study:

  • To identify key differentially expressed miRNAs (DEMs) and their target genes in FTC.
  • To analyze the interactions within a miRNA-mRNA regulatory network.
  • To explore potential diagnostic and therapeutic targets for FTC.

Main Methods:

  • Utilized gene microarray (GSE82208) and microRNA (GSE62054) datasets.
  • Employed bioinformatics tools (R, SAM, TargetScan, miRDB, miRTarBase, DAVID, STRING, MCODE, BiNGO) for data analysis.
  • Constructed and analyzed a protein-protein interaction (PPI) network.

Main Results:

  • Identified nine key DEMs potentially regulating hub genes like KIT and EGFR.
  • Enriched pathways included PI3K-Akt signaling and microRNAs in cancer.
  • A significant miRNA-mRNA interaction network associated with FTC was elucidated.

Conclusions:

  • The identified miRNA-mRNA network provides molecular support for differentiating malignant FTC from benign follicular adenoma (FTA).
  • These findings offer novel insights into potential diagnostic and therapeutic targets for FTC.

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