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Related Concept Videos

Cell Potential and Free Energy02:58

Cell Potential and Free Energy

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Thermodynamics of a Redox Reaction
Thermodynamics is the branch of physics dealing with the relationship between heat and other forms of energy. In an electrochemical cell, chemical energy is converted into electrical energy.
Thus, a link can be predicted between cell potential, free energy change, and the equilibrium constant for the reaction. Cell potential can also be measured as the oxidant or the reducing strength, and similar acid-base strength measures are reflected in equilibrium...
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Potential Energy00:52

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The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
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Potential Energy01:09

Potential Energy

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A conservative force, such as a gravitational or elastic force, gives the body the capacity to do work. This capacity, measured as the potential energy, depends on the body's location or “position” relative to a fixed reference position or datum. The gravitational potential energy is considered zero at the reference point. Suppose a body is located at some vertical distance above a fixed horizontal reference or datum. In that case, the weight of the body has positive gravitational potential...
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Standard Electrode Potentials03:02

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On comparing the reactivity of silver and lead, it is observed that the two ionic species, Ag+ (aq) and Pb2+ (aq), show a difference in their redox reactivity towards copper: the silver ion undergoes spontaneous reduction, while the lead ion does not. This relative redox activity can be easily quantified in electrochemical cells by a property called cell potential. This property is commonly known as cell voltage in electrochemistry, and it is a measure of the energy which accompanies the charge...
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The Resting Membrane Potential01:21

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Electric Potential and Potential Difference01:16

Electric Potential and Potential Difference

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Suppose a positive test charge moves away from a positive static charge, then the Coulomb force does positive work, and its electric potential energy decreases. The potential energy per unit charge is defined as the electric potential. The electric potential is independent of the test charge.
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Related Experiment Video

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Bioprinting of Hydrogel Tumor Slices as a 3D Model for Mantle Cell Lymphoma
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Signet Ring B Cell Lymphoma: A Potential Diagnostic Pitfall.

Shishou Wu1,2, Weifang Ding3, Xiaolong Sui2

  • 1Department of Clinical Medcine, Binzhou Medical College, No.346, Guanhai Road, Yantai, China.

Open Medicine (Warsaw, Poland)
|April 30, 2019
PubMed
Summary

Signet ring B cell lymphoma, a rare non-Hodgkin lymphoma, presents unique morphological challenges. This case highlights its distinct features and poor prognosis despite treatment.

Keywords:
Differential diagnosisLymphomaSignet ring cell

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Area of Science:

  • Hematology
  • Oncology
  • Pathology

Background:

  • Signet ring B cell lymphoma is a rare non-Hodgkin lymphoma.
  • Morphologically, it mimics signet ring cell carcinoma and liposarcoma, necessitating careful distinction.
  • Accurate diagnosis is crucial for appropriate patient management.

Purpose of the Study:

  • To report a case of signet ring B cell lymphoma in a 63-year-old male.
  • To describe the clinical, histological, and immunohistochemical features of this rare lymphoma.
  • To discuss the diagnostic challenges and treatment outcomes.

Main Methods:

  • A 63-year-old male patient presented with abdominal pain and enlarged retroperitoneal lymph nodes.
  • CT scan revealed multiple enlarged lymph nodes.
  • Needle biopsy with special staining (CD45, Vimentin, Bcl-2, CD20, AE1/AE3, S-100, CD3, EMA, CD5, CD10, Bcl-6, MUM1, Kappa, Lambda, PAS) and Ki67 proliferation index assessment was performed.

Main Results:

  • Histopathology showed neoplastic cells with clear cytoplasm and eccentrically placed nuclei, resembling signet rings.
  • Immunohistochemistry confirmed positivity for CD45, Vimentin, Bcl-2, and CD20, and negativity for other markers.
  • Ki67 proliferation index was over 80%.

Conclusions:

  • The histological and immunohistochemical findings supported the diagnosis of signet ring B cell lymphoma.
  • Despite R-CHOP therapy, the patient experienced tumor recurrence and died 34 months post-diagnosis.
  • This case underscores the aggressive nature and diagnostic complexities of signet ring B cell lymphoma.