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Updated: Jan 25, 2026

Severe Burn Injury in a Swine Model for Clinical Dressing Assessment
Published on: November 6, 2018
Weaning of Children With Burn Injury by Noninvasive Ventilation: A Clinical Experience
Marco Piastra1, Enzo Picconi1, Tony C Morena1
1Pediatric Intensive Care Unit, Department of Intensive Care Medicine, Anesthesiology and Emergency Medicine, Fondazione Policlinico Universitario A. Gemelli, Università Cattolica del Sacro Cuore, Rome, Italy.
Insights
Severe burn injuries in children often require mechanical ventilation, significantly increasing Pediatric Intensive Care Unit (PICU) stays. Noninvasive ventilation (NIV) showed potential benefits in reducing invasive ventilation time and complications for these pediatric patients.
Area of Science:
- Pediatric Critical Care Medicine
- Burn Injury Management
- Respiratory Support
Background:
- Severe burn injuries in pediatric patients frequently necessitate respiratory support.
- Mechanical ventilation is a common intervention in Pediatric Intensive Care Units (PICUs) for burned children.
- The length of PICU stay is significantly influenced by the need for ventilation and burn severity.
Purpose of the Study:
- To analyze the respiratory management strategies for infants and children with severe burn injuries admitted to a PICU.
- To evaluate the potential benefits of noninvasive ventilation (NIV) in reducing invasive mechanical ventilation requirements and associated complications.
Main Methods:
- Retrospective review of pediatric patients admitted to a PICU between 2009 and 2016.
- Analysis of data including age, burn characteristics (e.g., face burns), need for tracheal intubation, PICU length of stay, and ventilation strategies.
- Comparison of outcomes between patients who received NIV and those who did not.
Main Results:
- 118 pediatric patients with burn injuries were included; 37.3% required tracheal intubation and 30.5% had PICU stays exceeding 7 days.
- Ventilated patients experienced significantly longer PICU stays (13 days vs. 4.5 days).
- Noninvasive ventilation (NIV) was used in 10 patients; no significant difference in PICU length of stay or invasive ventilation duration was observed compared to non-NIV patients, despite larger burn surface areas in the NIV group.
Conclusions:
- Mechanical ventilation is a critical factor impacting PICU length of stay in pediatric burn patients.
- While NIV did not show a statistically significant difference in this cohort, it may offer potential benefits in shortening invasive ventilation duration and reducing complications.
- Further research is warranted to fully elucidate the role and efficacy of NIV in managing respiratory distress in severe pediatric burn injuries.
Abstract:
The aim of this study was to report the respiratory management of a cohort of infants admitted to a Pediatric Intensive Care Unit (PICU) over a 7-year period due to severe burn injury and the potential benefits of noninvasive ventilation (NIV). A retrospective review of all pediatric patients admitted to PICU between 2009 and 2016 was conducted. From 2009 to 2016, 118 infants and children with burn injury were admitted to our institution (median age 16 months [IQR = 12.2-20]); 51.7% of them had face burns, 37.3% underwent tracheal intubation, and 30.5% had a PICU stay greater than 7 days. Ventilated patients had a longer PICU stay (13 days [IQR = 8-26] vs 4.5 days [IQR = 2-13]). Both ventilation requirement and TBSA% correlated with PICU stay (r = .955, p < .0001 and r = .335, p = .002, respectively), while ventilation was best related in those >1 week (r = .964, p < .0001 for ventilation, and r = -.079, p = .680, for TBSA%). NIV was introduced in 10 patients, with the aim of shorten the invasive ventilation requirement. As evidenced in our work, mechanical ventilation is frequently needed in burned children admitted to PICU and it is one of the main factors influencing PICU length of stay. No difference was found in terms of PICU length of stay and invasive mechanical ventilation time between children who underwent NIV and children who did not, despite children who underwent NIV had a larger burn surface. NIV can possibly shorten the total invasive ventilation time and related complications.
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