Related Experiment Video For Mitochondria
Updated: Jan 25, 2026

Monitoring Dynamic Changes In Mitochondrial Calcium Levels During Apoptosis Using A Genetically Encoded Calcium Sensor
Published on: April 1, 2011
Mitochondrial calcium uniporter complex modulation in cancerogenesis
Saverio Marchi1,2, Veronica Angela Maria Vitto1, Alberto Danese1
1a Department of Morphology, Surgery and Experimental Medicine, Section of Pathology, Oncology and Experimental Biology , Laboratory for Technologies of Advanced Therapies (LTTA), University of Ferrara , Ferrara , Italy.
Abstract:
Aberrations in mitochondrial Ca2+ homeostasis have been associated with different pathological conditions, including neurological defects, cardiovascular diseases, and, in the last years, cancer. With the recent molecular identification of the mitochondrial calcium uniporter (MCU) complex, the channel that allows Ca2+ accumulation into the mitochondrial matrix, alterations in the expression levels or functioning in one or more MCU complex members have been linked to different cancers and cancer-related phenotypes. In this review, we will analyze the role of the uniporter and mitochondrial Ca2+ derangements in modulating cancer cell sensitivity to death, invasiveness, and migratory capacity, as well as cancer progression in vivo. We will also discuss some critical points and contradictory results to highlight the consequence of MCU complex modulation in tumor development.
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