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Noncoding RNAs as circulating biomarkers in osteosarcoma patients.

Gerardo Botti1, Antonio Giordano2,3, Florinda Feroce4

  • 1Scientific Direction, Istituto Nazionale Tumori-Irccs-Fondazione G.Pascale, Naples, Italy.

Journal of Cellular Physiology
|April 30, 2019
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Noncoding RNAs (ncRNAs) are promising blood biomarkers for osteosarcoma. Their levels change with disease progression and treatment, aiding in monitoring patient status.

Keywords:
circulating miRNAscirculating ncRNAsosteosarcoma

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Noncoding RNAs (ncRNAs) are crucial in tumor pathogenesis and progression.
  • ncRNAs are found in patient blood, indicating potential as circulating biomarkers.
  • ncRNAs, including miRNAs and lncRNAs, are frequently deregulated in sarcoma, particularly osteosarcoma.

Purpose of the Study:

  • To review studies on circulating ncRNAs as biomarkers in osteosarcoma.
  • To highlight the potential of ncRNAs in monitoring osteosarcoma progression and therapy response.

Main Methods:

  • Literature review of studies investigating ncRNAs in osteosarcoma.
  • Analysis of data on ncRNA expression in tumor tissues and biological fluids.
  • Focus on circulating ncRNAs (miRNAs, lncRNAs) in blood samples.

Main Results:

  • ncRNAs are deregulated in osteosarcoma tissues.
  • Circulating ncRNAs show altered expression levels correlating with disease status.
  • ncRNA expression varies during osteosarcoma progression and in response to treatment.

Conclusions:

  • Circulating ncRNAs are valuable emerging biomarkers for osteosarcoma.
  • ncRNAs can potentially monitor disease progression and therapeutic efficacy in osteosarcoma patients.