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Published on: September 5, 2016
[Arteriosclerosis and chelate therapy]
Wiener Medizinische Wochenschrift (1946)
|November 30, 1986
Summary
Intravenous chelation therapy using ethylenediaminetetraacetate (EDTA) for arteriosclerosis is questionable. While proposed to remove calcium deposits, its effectiveness lacks in-vivo proof and carries risks like fatal hypocalcemia.
Area of Science:
- Cardiovascular Medicine
- Toxicology
- Pharmacology
Background:
- Arteriosclerosis involves calcium deposition in arterial lesions.
- Ethylenediaminetetraacetate (EDTA) is a chelating agent primarily used for heavy metal poisoning treatment.
- Intravenous chelation therapy has been anecdotally proposed for arteriosclerosis.
Observation:
- A case history is presented to discuss the therapeutic value of intravenous chelation therapy in arteriosclerosis.
- The mechanism suggested involves the removal of calcium (Ca) deposits from arteriosclerotic lesions by EDTA.
- This proposed mechanism has not been substantiated by in-vivo experimental evidence.
Findings:
- The therapeutic efficacy of EDTA chelation therapy for arteriosclerosis remains doubtful.
- Clinical use is not supported by robust in-vivo experimental data.
- Significant adverse effects, including potentially fatal hypocalcemia, are associated with EDTA treatment.
Implications:
- Current evidence does not support the use of EDTA for treating arteriosclerosis.
- The risks associated with EDTA chelation therapy outweigh any unproven benefits.
- Further research is needed to validate or refute the proposed mechanisms and assess safety in cardiovascular conditions.
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