[Clinical use of Gonadorelin as a diagnostic agent in one- and two-step tests]

Synthetic LH/RH Gonadorelin, produced by VEB Berlin-Chemie, was given to 11 women with a normal menstrual cycle during the middle of the follicle phase. It was proved as a very effective drug, which provoked a typical gonadotropin release. Also 10 patients with a secondary amenorrhea responded already to the first intravenous injection of 80 micrograms Gonadorelin with a peak level of gonadotropins, in particular with LH levels, after 30 to 60 minutes (delta 1 = 1 st peak level--0' level). The relative ascent of gonadotropins (delta 2 = 2nd peak level--120' level) after the second step i.v. administration of 80 micrograms Gonadorelin at a 120 minutes interval was not significantly higher than delta 1. The reaction of pituitary on LH/RH does not immediately depend on the basal level of gonadotropin values. It reflects the severity of the hypothalamic-pituitary functional disturbance. The "Gonadorelin-test" ist a good complement to the progesterone- and clomiphene-test.