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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

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The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
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Multipotency and Niche of Bulge Stem Cell01:06

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A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
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Ecological Niches02:02

Ecological Niches

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All organisms have a position within an ecosystem. The complete set of living and nonliving factors—including food resources, climate, and terrain—that define the position of a given organism are collectively referred to as the organism’s ecological niche.
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Adult Stem Cells01:33

Adult Stem Cells

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Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously...
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Embryonic Stem Cells00:58

Embryonic Stem Cells

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Embryonic stem (ES) cells are undifferentiated pluripotent cells, meaning they can produce any cell type in the body. This gives them tremendous potential in science and medicine since they can generate specific cell types for use in research or to replace body cells lost due to damage or disease.
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Normal Stress01:19

Normal Stress

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Normal stress is a type of stress that occurs when forces act perpendicular, or normal, to a material's cross-sectional area. This stress often arises in structures when subjected to axial loading, which is the application of force along the axis of an object. A practical example of this can be found in bridge truss members.
When a rod is under axial loading, the internal forces and corresponding stress are normal to the plane of the section, so it is termed normal stress. It's important to...
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Updated: Jan 25, 2026

The Organoid Reconstitution Assay ORA for the Functional Analysis of Intestinal Stem and Niche Cells
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Normal and leukemic stem cell niche interactions.

Il-Hoan Oh1,2, Seon-Yeong Jeong1, Jin-A Kim1

  • 1Catholic High-Performance Cell Therapy Center.

Current Opinion in Hematology
|April 30, 2019
PubMed
Summary
This summary is machine-generated.

Leukemic stem cells reprogram the bone marrow niche to support their growth. This reprogramming offers potential for novel therapies targeting the niche to revert it to an anti-leukemic state.

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Author Spotlight: Standardizing Limbal Niche Cell (LNC) Isolation and Characterization to Support Widespread LNC Research
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Area of Science:

  • Hematology
  • Cancer Biology
  • Stem Cell Biology

Background:

  • Hematopoietic stem cells (HSCs) and leukemic stem cells (LSCs) interact differently with the bone marrow stem cell niche.
  • Understanding the unique microenvironmental regulation of LSCs is crucial for deciphering in-vivo leukemogenesis and developing new therapies.

Purpose of the Study:

  • To explore the dynamic interactions between leukemic cells and the bone marrow microenvironment.
  • To investigate the potential for therapeutic manipulation of the stem cell niche in leukemia.

Main Methods:

  • Review of current literature on stem cell niche interactions in leukemia.
  • Analysis of mechanisms by which leukemic cells reprogram the bone marrow microenvironment.

Main Results:

  • Leukemic cells reprogram mesenchymal stromal cells within the niche, creating a pro-leukemic environment.
  • Niche remodeling by leukemic cells influences leukemogenesis and clinical prognosis.
  • Niche cells can be stimulated to adopt anti-leukemic properties.

Conclusions:

  • The bone marrow microenvironment plays an active, dynamic role in supporting leukemogenesis.
  • Targeting and reprogramming the stem cell niche presents a promising therapeutic strategy for leukemia.