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Related Experiment Videos

Descemet's stripping without endothelial keratoplasty.

Daniel Garcerant1, Nino Hirnschall1,2, Nicholas Toalster1

  • 1Sydney Eye Hospital.

Current Opinion in Ophthalmology
|April 30, 2019
PubMed
Summary

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Descemet's stripping only (DSO) is a growing surgical option for Fuchs' Dystrophy. Topical Rho-kinase inhibitors show promise in improving DSO success rates and salvaging cases.

Area of Science:

  • Ophthalmology
  • Corneal Surgery
  • Regenerative Medicine

Background:

  • Fuchs' Dystrophy is a progressive corneal disease affecting endothelial cells.
  • Descemetorhexis Stripping without Endothelial Keratoplasty (DWEK), or Descemet's Stripping Only (DSO), is an emerging alternative to traditional endothelial keratoplasty.
  • Understanding the clinical, confocal, and histological characteristics of DSO is crucial for optimizing patient outcomes.

Purpose of the Study:

  • To review current literature on Descemet's Stripping Only (DSO).
  • To detail the clinical, confocal, and histological findings associated with DSO procedures.
  • To assess the efficacy and potential adjuncts for DSO in managing Fuchs' Dystrophy.

Main Methods:

  • Literature review of recent studies on DSO.

Related Experiment Videos

  • Analysis of clinical, confocal microscopy, and histological data from DSO patients.
  • Examination of the role of topical Rho-kinase inhibitors in DSO outcomes.

    • Main Results:

    • DSO exhibits reported clearance rates between 63% and 100%, varying by surgical technique.
    • Topical Rho-kinase inhibitors demonstrate success in managing failing DSO cases and are increasingly adopted.
    • While surgical factors influencing DSO success are understood (e.g., minimizing stromal injury), patient-specific predictors remain unclear.

    Conclusions:

    • DSO is increasingly accepted for select Fuchs' Dystrophy patients.
    • Rho-kinase inhibitors may enhance DSO predictability, though further validation is required.
    • Continued research and scrutiny of DSO outcomes, particularly with adjunct therapies, are necessary.