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Corneal neurotization.
1Cornea, Anterior Segment and Refractive Surgery Department, University of Ottawa Eye Institute, Ottawa, Ontario, Canada.
Current Opinion in Ophthalmology
|April 30, 2019
Summary
Corneal neurotization shows promise for treating neurotrophic keratopathy by restoring corneal nerves. While still invasive, this technique offers a potential cure for this debilitating condition.
Area of Science:
- Ophthalmology
- Regenerative Medicine
- Neurosurgery
Background:
- Neurotrophic keratopathy causes corneal anesthesia, leading to potential blindness.
- Existing treatments fail to address corneal sensation loss effectively.
- Corneal nerve regeneration is crucial for treating this condition.
Purpose of the Study:
- Review current surgical advances in corneal neurotization.
- Discuss evidence for corneal nerve regeneration.
- Explore new thoughts on treating neurotrophic keratopathy.
Main Methods:
- Review of recent literature on corneal neurotization techniques.
- Analysis of surgical approaches including direct and indirect neurotization.
- Inclusion of endoscopic techniques for minimally invasive procedures.
Main Results:
- Corneal neurotization, introduced in 2009, gained traction since 2014.
- Various nerves (sural, great auricular) are explored for corneal reinnervation.
- Confocal microscopy and esthesiometry confirm corneal nerve regeneration within 6 months post-procedure.
Conclusions:
- Corneal neurotization is a promising, revolutionary technique for neurotrophic corneas.
- The procedure is currently invasive and suitable for selected patients.
- Further research may refine techniques and expand patient eligibility.
