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Increasing Diagnostic Uncertainties in Children With In Utero HIV Infection
Jane R Millar1,2, Zodumo Mvo1, Nomonde Bengu1
1Umkhuseli Innovation and Research Management, Pietermaritzburg, South Africa.
Abstract:
We present a case of an in utero HIV-infected child, who on day 1 of life had a positive whole blood total nucleic acid test but viral load <20 RNA copies/mL. Dried blood spot total nucleic acid testing was negative on day 1, 10 and at 3 months, while on ART prophylaxis then positive at 5 months after prophylaxis ended. Retrospective peripheral blood mononuclear cells HIV DNA testing from day 1 of life was positive, confirming in utero infection.
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