Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.4K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Self-Evaluation: Self-Enhancement and Self-Verification03:00

Self-Evaluation: Self-Enhancement and Self-Verification

5.8K
Social psychologists have documented that feeling good about ourselves and maintaining positive self-esteem is a powerful motivator of human behavior (Tavris & Aronson, 2008). In the United States, members of the predominant culture typically think very highly of themselves and view themselves as good people who are above average on many desirable traits (Ehrlinger, Gilovich, & Ross, 2005). Often, our behavior, attitudes, and beliefs are affected when we experience a threat to our...
5.8K
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

250
Body:Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
250
Group Therapy01:26

Group Therapy

403
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
403
Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

195
Body:After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt...
195
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

205
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
205

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Population Pharmacokinetics of Intravenous Infusion of Hydromorphone in Critically Ill Patients Supported by Extracorporeal Membrane Oxygenation.

Clinical and translational science·2026
Same author

Autonomously Motile Nano-PROTACs Act as Protein-Sweeping Robots to Enhance Targeted Protein Degradation.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Corrigendum to "Loneliness trajectories and long-term frailty in the english longitudinal study of ageing: The mediating role of depression". Archives of Gerontology and Geriatrics 2026Jul:146:106210.

Archives of gerontology and geriatrics·2026
Same author

Biological Aging Mediates the Associations Between Multiple Serum Micronutrients and All-Cause Mortality Among U.S. Adults.

Biological trace element research·2026
Same author

Ziftomenib with venetoclax and azacitidine in relapsed/refractory NPM1-mutated acute myeloid leukemia.

Blood·2026
Same author

A predictive model for metastatic colorectal cancer based on immune cells and tumor markers.

Langenbeck's archives of surgery·2026

Related Experiment Video

Updated: Jan 25, 2026

Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.8K

Sequential Intercellular Delivery Nanosystem for Enhancing ROS-Induced Antitumor Therapy.

Binghua Wang1,2,3, Huifang Zhang1, Jingyi An1

  • 1School of Pharmaceutical Sciences , Zhengzhou University , Zhengzhou 450001 , China.

Nano Letters
|April 30, 2019
PubMed
Summary

This study introduces a novel delivery system for enhanced reactive oxygen species (ROS) therapy in tumors. The system targets deep tumor regions, improving ROS generation and antitumor efficacy.

Keywords:
Photodynamic therapyextracellular vesicleslinoleic acid hydroperoxidemembrane fusion liposomenano FeOreactive oxygen species

More Related Videos

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
08:22

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Published on: July 18, 2019

9.1K
Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery
10:51

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Published on: August 7, 2014

9.0K

Related Experiment Videos

Last Updated: Jan 25, 2026

Studying Cavitation Enhanced Therapy
07:36

Studying Cavitation Enhanced Therapy

Published on: April 9, 2021

5.8K
Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery
08:22

Delivery of Antibodies into the Murine Brain via Convection-enhanced Delivery

Published on: July 18, 2019

9.1K
Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery
10:51

Microscale Vortex-assisted Electroporator for Sequential Molecular Delivery

Published on: August 7, 2014

9.0K

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Cancer Therapy

Background:

  • Photodynamic therapy (PDT) efficacy is limited by challenges in reactive oxygen species (ROS) generation, particularly in hypoxic tumor environments.
  • Deep-seated hypoxic tumor regions are often inaccessible for effective ROS-based treatment.
  • Existing strategies often neglect the unique challenges posed by deep tumor penetration and accessibility.

Purpose of the Study:

  • To develop a sequential intercellular delivery system for enhanced ROS-based cancer therapy.
  • To overcome the limitations of accessibility in deep hypoxic tumor regions.
  • To improve the overall efficiency of malignancy tumor treatment using ROS.

Main Methods:

  • Construction of a sequential intercellular delivery system (MFLs/LAOOH@DOX) using membrane fusion liposomes (MFLs) containing linoleic acid hydroperoxide (LAOOH) and doxorubicin (DOX).
  • LAOOH was utilized as a ROS-generating agent, dependent on Fe2+ for ROS production.
  • The system leverages the enhanced permeation and retention (EPR) effect for tumor cell membrane fusion and subsequent intercellular spread via extracellular vesicles.

Main Results:

  • MFLs/LAOOH@DOX demonstrated fusion with tumor cell membranes, delivering LAOOH and releasing DOX.
  • LAOOH effectively spread throughout the tumor via extracellular vesicle hitchhiking, reaching neighboring cells.
  • Co-administration with nano Fe3O4 enabled specific ROS generation on tumor cell membranes, enhancing treatment throughout the tumor.

Conclusions:

  • The developed sequential intercellular delivery system effectively overcomes accessibility issues in deep tumor regions.
  • LAOOH-mediated ROS generation, enhanced by Fe2+ and targeted delivery, significantly improves antitumor treatment efficiency.
  • This study presents a promising new strategy for enhancing ROS-based antitumor therapies.