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Updated: Jan 25, 2026
Enema of Traditional Chinese Medicine for Patients with Severe Acute Pancreatitis
Published on: January 27, 2023
Multicenter investigation of hemostatic dysfunction in 15 dogs with acute pancreatitis
Lindsey Nielsen1, Jennifer Holm1, Elizabeth Rozanski2
1Angell Memorial Animal Hospital, Boston, MA.
Objective:
To characterize hemostatic profiles in dogs with acute pancreatitis.
Design:
Prospective and observational study.
Setting:
Tertiary referral centers.
Animals:
Fifteen client-owned dogs with acute pancreatitis enrolled between December 1, 2011 and June 1, 2012.
Materials And Methods:
Blood samples were collected on admission for measurement of platelet count, PCV, thromboelastography (TEG), antithrombin, prothrombin time, activated partial thromboplastin time, D-dimer, von Willebrand factor, and fibrinogen values, which were compared to reference intervals derived from healthy dogs. The Wilcoxon rank-sum test was used to test for differences in continuous variables between study subjects and reference intervals.
Measurements And Main Results:
Dogs with acute pancreatitis were globally hypercoagulable using TEG when compared with reference intervals. Dogs with acute pancreatitis had significantly higher D-dimers (1,144 μg/L vs 251 μg/L [6264.5 vs 1374.5 nmol/L]; P = 0.001), fibrinogen (837 vs 232 mg/dL [8.37 vs 2.32 g/L]; P < 0.001), and von Willebrand factor (92.9% vs 65.1%; P = 0.02) as well as significantly lower antithrombin (85.7% vs 120%; P < 0.001) and prothrombin time values (3.8 vs 7.6 sec; P < 0.001) than reference intervals.
Conclusions:
Laboratory evidence of hypercoagulability was present in dogs with acute pancreatitis. TEG may be useful in dogs with acute pancreatitis for monitoring response to therapy and guiding therapeutic interventions.
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