Related Experiment Video

Updated: Jan 25, 2026

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence
10:09

Methods for Evaluating the Role of c-Fos and Dusp1 in Oncogene Dependence

Published on: January 7, 2019

8.7K

Essential role of O-GlcNAcylation in stabilization of oncogenic factors

Vivek Makwana1, Philip Ryan1, Bhautikkumar Patel1

  • 1School of Pharmacy and Pharmacology, Griffith University, Gold Coast, Queensland 4222, Australia.

Biochimica Et Biophysica Acta. General Subjects
|April 30, 2019
PubMed

Insights

O-GlcNAcylation, a protein modification, competes with phosphorylation and drives cancer progression by affecting oncogenic factors. Understanding this process may lead to new cancer therapies targeting O-GlcNAc transferase (OGT).

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cancer Biology

Background:

  • O-GlcNAcylation is a reversible post-translational modification.
  • It competes with phosphorylation and is catalyzed by O-linked β-N-acetylglucosamine transferase (OGT).
  • Hyper-O-GlcNAcylation is a hallmark of many cancers, promoting proliferation and progression.

Purpose of the Study:

  • To highlight the interplay between oncogenic factors and O-GlcNAcylation.
  • To explore the role of OGT in cancer cell proliferation and survival.
  • To discuss the therapeutic potential of OGT inhibitors in cancer treatment.

Main Methods:

  • Review of existing literature on O-GlcNAcylation and cancer.
  • Analysis of the connection between O-GlcNAcylation and key oncogenic factors (e.g., c-MYC, HIF-1α, NF-κB).
  • Discussion of the enzymatic activity of OGT and its role in cancer metabolism.

Main Results:

  • O-GlcNAcylation significantly influences cancer cell metabolism and proliferation.
  • O-GlcNAcylation is linked to major oncogenic factors crucial for cancer progression.
  • OGT plays a critical role in mediating these effects.

Conclusions:

  • O-GlcNAcylation is a key regulator of cancer cell proliferation and survival.
  • Targeting OGT may offer a promising therapeutic strategy for various cancers.
  • Further research into O-GlcNAc modification of oncogenic factors is warranted for improved cancer diagnosis and therapy.
Keywords:
O-GlcNAcylationOGT enzymeOGT inhibitorsOncogenic factors

More Related Videos

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis09:58

Mapping the Structure-Function Relationships of Disordered Oncogenic Transcription Factors Using Transcriptomic Analysis

Published on: June 27, 2020

3.1K
Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line06:24

Oncogene Expression Analysis with Alterations in pH in a Pancreatic Ductal Cell Line

Published on: April 11, 2025

888

Related Concept Videos

Role of Hematopoietic Growth Factors01:28

Role of Hematopoietic Growth Factors

Hematopoietic growth factors are molecules that regulate the differentiation rate of hematopoietic stem cells (HSCs). Erythropoietin (EPO), primarily produced by the kidneys, plays a crucial role in erythrocyte production. When oxygen levels in the blood are low, EPO is released into the bloodstream, reaching the bone marrow, where it stimulates HSCs to differentiate and mature into erythrocytes, which are vital for oxygen transport.
Thrombopoietin (TPO), mainly released by the liver,...
3.3K
RNA Stability01:53

RNA Stability

Intact DNA strands can be found in fossils, while scientists sometimes struggle to keep RNA intact under laboratory conditions. The structural variations between RNA and DNA underlie the differences in their stability and longevity. Because DNA is double-stranded, it is inherently more stable. The single-stranded structure of RNA is less stable but also more flexible and can form weak internal bonds. Additionally, most RNAs in the cell are relatively short, while DNA can be up to 250 million...
35.7K
Complexation Equilibria: Factors Influencing Stability of Complexes01:09

Complexation Equilibria: Factors Influencing Stability of Complexes

In complexation reactions, metal cations are the electron pair acceptors, and the ligands are the electron pair donors. The stability of the metal complexes depends primarily on the complexing ability of the central metal ion and the nature of the ligands. Generally, the complexing ability of the metal ion depends on the size and charge of the ion. As the metal ion size increases, the stability of the metal complexes decreases, provided that the valency of the metal ion and the ligands remain...
814
Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry01:20

Factors Affecting Dissolution: Drug Permeability, Stability and Stereochemistry

Orally administered drugs primarily enter the systemic circulation via passive diffusion through the intestinal membranes. The drug's absorption is influenced by drug stability in the gastrointestinal GI tract, membrane permeability, the surface area available for absorption, luminal drug concentration, and residence time in the lumen. Drug permeability can be enhanced by adjusting the lipophilicity, polarity, or molecular size of the drug, promoting its passive transport across intestinal...
516
Compounds Essential to Human Function01:25

Compounds Essential to Human Function

The human body is composed of cells that are fundamentally made up of several different molecules. These molecules are essential to carry out all physiological processes in the body and are broadly classified into organic and inorganic based on their chemical structures.
Inorganic Compounds Essential to Human Functioning
Inorganic compounds essential to human functioning include water, salts, acids, and bases. These compounds are inorganic, i.e., they do not have a carbon-hydrogen bond. Water...
10.1K
Nuclear Stability03:18

Nuclear Stability

Protons and neutrons, collectively called nucleons, are packed together tightly in a nucleus. With a radius of about 10−15 meters, a nucleus is quite small compared to the radius of the entire atom, which is about 10−10 meters. Nuclei are extremely dense compared to bulk matter, averaging 1.8 × 1014 grams per cubic centimeter. If the earth’s density were equal to the average nuclear density, the earth’s radius would be only about 200 meters.
To hold positively charged protons together...
23.0K