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Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma

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Published on: November 4, 2010

Association Between Pulmonary Function and Asthma Symptoms.

Patrick W Sullivan¹, Vahram H Ghushchyan², Jessica Marvel³

¹Regis University School of Pharmacy, Denver, Colo.

The Journal of Allergy and Clinical Immunology. in Practice

|April 30, 2019

Summary

Pulmonary function (FEV₁%pred) and asthma control questionnaires (ACQ) showed a weak association initially. Adjusted analysis revealed significant links, emphasizing the need for both measures in asthma management.

Keywords:

ACQ Asthma Control FEV(1)Longitudinal Lung function OSACO Pulmonary function

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Area of Science:

Pulmonary Medicine
Clinical Research
Asthma Management

Background:

Forced expiratory volume in 1 second as a percentage of predicted (FEV₁%pred) is a standard metric in asthma studies.
Its correlation with asthma control instruments, particularly symptom-based questionnaires, remains inconsistently reported.

Purpose of the Study:

To evaluate the relationship between FEV₁%pred and Asthma Control Questionnaire (ACQ) scores.
To assess this association within a managed-care population experiencing persistent asthma.

Main Methods:

A retrospective analysis utilized spirometry results and survey data from 1748 patients (≥12 years) with persistent asthma.
Longitudinal analyses and regression models, with and without covariate adjustments, were employed.

Main Results:

Unadjusted models showed no significant association between FEV₁%pred and ACQ scores (R²=0.03).
Adjusted models demonstrated a significant inverse relationship: a 1-point increase in ACQ-5/ACQ-6 scores correlated with a 1.7%/1.9% decrease in FEV₁%pred (P < .001), with R² increasing to 0.11/0.12.
Changes in FEV₁%pred and ACQ scores over time were not significantly associated.

Conclusions:

Initial unadjusted analyses indicated substantial unexplained variability between FEV₁%pred and ACQ scores.
Findings support integrating both pulmonary function tests and symptom-based assessments for comprehensive asthma control evaluation in clinical and research settings.