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The role of microtubules in the immune system and as potential targets for gut-based immunotherapy

Tahel Ilan-Ber1, Yaron Ilan2

  • 1Oberon Sciences Israel, Israel.

Molecular Immunology
|April 30, 2019
PubMed

Insights

Microtubules (MTs), crucial for cell structure, are increasingly recognized for their roles in the immune system, particularly in the gut. This review explores MTs as potential targets for novel oral immunotherapies.

Area of Science:

  • Cell Biology
  • Immunology
  • Gastroenterology

Background:

  • Microtubules (MTs) are dynamic cytoskeletal polymers essential for cellular structure and function.
  • Emerging evidence highlights MTs' involvement in both innate and adaptive immune responses.
  • Specific roles for MTs within the gastrointestinal tract are gaining attention.

Purpose of the Study:

  • To review recent findings on the interactions between microtubules and the immune system.
  • To explore the potential of gut microtubules as therapeutic targets.
  • To propose a model for the use of gut MTs in oral immunotherapy.

Main Methods:

  • Literature review of recent studies on microtubule structure, function, and immunology.
  • Analysis of data linking microtubule dynamics to immune cell activity.
  • Synthesis of information to develop a conceptual model for immunotherapy.

Main Results:

  • Microtubules play multifaceted roles in immune cell function and regulation.
  • The gut environment presents unique interactions between microtubules and immune components.
  • Existing data supports the hypothesis that microtubules can be targeted therapeutically.

Conclusions:

  • Gut microtubules represent a promising, yet underexplored, target for immunomodulation.
  • Targeting gut microtubules could lead to innovative strategies for oral immunotherapy.
  • Further research is warranted to elucidate the precise mechanisms and therapeutic potential.
Keywords:
GlycosphingolipidsGut immune systemMicrotubulesNKT cellsOral immunotherapy

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