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Updated: Jan 25, 2026

Gene Editing of Primary Rhesus Macaque B Cells
Published on: February 10, 2023
Hypertrophic osteoarthropathy in an adult macaque
1Institute of Archaeology, University College London, 31-34 Gordon Square, London, WC1H 0PY, United Kingdom.
Objective:
To evaluate through differential diagnosis whether hypertrophic osteoarthropathy was present on an adult macaque skeleton.
Materials:
Skeletal remains of a well-preserved adult macaque (Macaca) of unknown species curated by the archaeology department at University College London.
Methods:
Macroscopic and radiographic evaluation of pathological lesions.
Results:
Widespread bilateral and symmetrical periosteal new bone growth primarily affecting the limbs was observed.
Conclusion:
A careful differential diagnosis of the lesions and comparison with previously published cases of hypertrophic osteoarthropathy among humans and non-humans suggests this animal displays a case of Hypertrophic osteoarthropathy.
Significance:
Only been three reported cases of HOA in non-human primates have been reported, and all were apes. This study serves as the first reported case of HOA among non-hominoid simians, providing a detailed description of the skeletal lesions to aid future with paleopathological analyses.
Limitations:
Small sample sizes for comparison and lack of context for this specimen limits discussion of the scope of this disease among non-human primates.
Suggestions For Further Research:
Re-evaluate skeletal collections which have not been subject to recent osteological and pathological analysis.
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