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Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
Cholesterol Trafficking: An Emerging Therapeutic Target for Angiogenesis and Cancer
Junfang Lyu1, Eun Ju Yang2, Joong Sup Shim3
1Cancer Centre, Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China. junfanglyu@um.edu.mo.
Abstract:
Cholesterol is an essential structural component of cellular membranes. In addition to the structural role, it also serves as a precursor to a variety of steroid hormones and has diverse functions in intracellular signal transduction. As one of its functions in cell signaling, recent evidence suggests that cholesterol plays a key role in regulating angiogenesis. This review discusses the role of cholesterol in angiogenesis, with a particular emphasis on cholesterol trafficking in endothelial cell signaling. Small molecule inhibitors of cholesterol trafficking and their preclinical and clinical development targeting angiogenesis and cancer are also discussed.
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