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Related Concept Videos

Self-Help Support Groups01:28

Self-Help Support Groups

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Self-help support groups are voluntary, community-based organizations that provide a platform for individuals with shared concerns to exchange support, insights, and practical strategies for coping with life challenges. Typically led by group members or paraprofessionals, these groups form a cornerstone of mental health care, especially in reaching populations that are underserved by traditional healthcare systems.
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Non-gated Ion Channels

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Ion channels are specialized proteins on the plasma membrane that allow charged ions to pass down their electrochemical gradient. Their main function is to maintain the membrane potential which is critical for cell viability. These channels are either gated or non-gated and can transport more than a thousand ions within milliseconds for the cellular event to occur.
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PolyJet 3D-Printed Enclosed Microfluidic Channels without Photocurable Supports.

Andre D Castiaux1, Cody W Pinger2, Elizabeth A Hayter1

  • 1Department of Chemistry , Saint Louis University , 3501 Laclede Ave. , St. Louis , Missouri 63103 , United States.

Analytical Chemistry
|May 1, 2019
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This study introduces a novel 3D-printing method for microfluidic devices, eliminating difficult support material removal. This technique enables rapid fabrication of complex microfluidic chips with minimal postprocessing for diverse applications.

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Area of Science:

  • Additive Manufacturing
  • Microfluidics
  • Biotechnology

Background:

  • Traditional microfluidic device fabrication relies on photolithography and etching.
  • PolyJet 3D-printing offers high accuracy but requires challenging support material removal for internal channels, especially in complex geometries.
  • Difficulty in removing support material hinders the fabrication of microfluidic devices with small or intricate channel designs.

Purpose of the Study:

  • To develop a simplified fabrication method for microfluidic devices using PolyJet 3D-printing.
  • To overcome the limitations of support material removal in 3D-printed microfluidic channels.
  • To enable rapid and efficient production of microfluidic devices with complex channel geometries.

Main Methods:

  • Utilized PolyJet 3D-printing with printer software manipulation to create sealed microfluidic channels.
  • Employed a two-step printing process: first printing a model with an open channel sealed by a liquid or membrane, then printing a second model on top.
  • Demonstrated fabrication of channels with cross-sections from 0.6 cm x 1.5 cm down to 125 μm x 54 μm, including serpentine and Y-mixer designs.

Main Results:

  • Achieved minimal to no postprocessing required for sealed microfluidic channels.
  • Successfully printed complex channel geometries like serpentine and Y-mixers in under 2 hours.
  • Validated device utility through an on-chip ATP release assay measuring red blood cell behavior.

Conclusions:

  • The developed 3D-printing technique significantly simplifies microfluidic device fabrication.
  • This method allows for rapid, cost-effective production of microfluidic devices with intricate designs.
  • The technique is suitable for various applications, including biological assays and lab-on-a-chip systems.