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Related Experiment Video

Updated: Jan 25, 2026

Isolation of Adipose Tissue Immune Cells
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Lymphocytes upregulate CD36 in adipose tissue and liver.

Jacob Couturier1, Alli M Nuotio-Antar2, Neeti Agarwal3

  • 1a Division of Infectious Diseases, Department of Internal Medicine , The University of Texas Health Science Center at Houston , Houston , TX , USA.

Adipocyte
|May 1, 2019
PubMed
Summary

T cells in adipose tissue and liver upregulate CD36, a lipid transporter. This CD36 upregulation suggests a distinct T cell phenotype in these metabolic tissues.

Keywords:
Adipose tissueCD36T cellsmetabolismobesity

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Area of Science:

  • Immunology
  • Metabolic research
  • Cell biology

Background:

  • CD36 is a scavenger receptor and lipid transporter involved in metabolic and inflammatory diseases.
  • CD36 expression is known in adipocytes and immune cells like macrophages, but its role in T cells is unclear.

Purpose of the Study:

  • To investigate CD36 expression in T cells within metabolic tissues.
  • To determine if T cells in adipose tissue and liver exhibit unique CD36 expression patterns.

Main Methods:

  • Flow cytometry analysis of CD36 expression on CD4+ and CD8+ T cells.
  • Comparison of T cells from adipose tissue, liver, blood, spleen, and lymph nodes in humans, monkeys, and mice.
  • Assessment of CD36 expression changes in response to high-fat diet in mice.

Main Results:

  • CD36 was upregulated in CD4+ and CD8+ T cells residing in adipose tissue and liver (5-40% CD36+).
  • T cells in blood, spleen, and lymph nodes showed minimal CD36 expression.
  • In monkeys, CD36 was primarily on resting T cells (CD38-, HLA-DR-, PD-1-) in adipose tissue.
  • High-fat feeding increased CD36 expression in mouse adipose tissue T cells.

Conclusions:

  • Adipose tissue and liver environments induce a distinct T cell phenotype characterized by CD36 upregulation.
  • CD36 expression in tissue-resident T cells may play a role in metabolic regulation and inflammation.