Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Dimensional Analysis03:40

Dimensional Analysis

60.7K
Dimensional analysis, also known as the factor label method, is a versatile approach for mathematical operations. The main principle behind this approach is: the units of quantities must be subjected to the same mathematical operations as their associated numbers. This method can be applied to computations ranging from simple unit conversions to more complex and multi-step calculations involving several different quantities and their units.
Conversion Factors and Dimensional Analysis
The unit...
60.7K
Dimensional Analysis01:27

Dimensional Analysis

654
Dimensional analysis is a valuable technique in fluid mechanics for simplifying complex problems by reducing them into dimensionless groups. These groups capture the essential relationships between the variables involved, allowing researchers and engineers to analyze fluid flow without dealing with each variable individually. This approach reduces the number of independent variables, allowing for easier analysis and better understanding of physical phenomena.
In fluid mechanics, dimensional...
654
Dimensional Analysis01:23

Dimensional Analysis

2.1K
Dimensional analysis is a powerful tool that is used in physics and engineering to understand and predict the behavior of physical systems. The basic idea behind dimensional analysis is to express physical quantities in terms of fundamental dimensions such as the mass, length, and time. Derived dimensions like the velocity, acceleration, and force are derived from the combinations of these fundamental dimensions.
Dimensional analysis allows us to analyze and compare physical quantities on a...
2.1K
Dimensional Analysis02:19

Dimensional Analysis

23.8K
The concept of dimension is important because every mathematical equation linking physical quantities must be dimensionally consistent, implying that mathematical equations must meet the following two rules. The first rule is that, in an equation, the expressions on each side of the equal sign must have the same dimensions. This is fairly intuitive since we can only add or subtract quantities of the same type (dimension). The second rule states that, in an equation, the arguments of any of the...
23.8K
Cell Size01:22

Cell Size

126.6K
Cell sizes vary widely among and within organisms. Bacterial cells range between 1-10 micrometers (μm)and are considerably smaller than most eukaryotic cells. The smallest bacteria are 0.1 μm in diameter—about a thousand times smaller than eukaryotic cells, which typically range from 10-100 μm.
Surface Area
Cells can take in nutrients and water via diffusion through the plasma membrane itself or through specific channels in the membrane. The area of the membrane surrounding...
126.6K
Three-Dimensional Force System01:30

Three-Dimensional Force System

2.8K
In mechanical engineering, a three-dimensional force system is a system of forces acting in three dimensions, with forces applied along the x, y, and z coordinate axes. The three-dimensional force system is an important concept in mechanical engineering, as it allows engineers to understand and analyze the behavior of objects and structures in three dimensions. By understanding the forces acting on a system, engineers can design more efficient and effective mechanical systems that can withstand...
2.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A role for nucleolin in functional improvement in stroke.

iScience·2026
Same author

Multiple mTOR RNA localization signals regulate subcellular protein synthesis and axonal growth.

bioRxiv : the preprint server for biology·2026
Same author

Reading the SINEs - functionality in noncoding RNA 'cheap genes'.

RNA biology·2026
Same author

Subcellular depletion of importin β1 impairs presynaptic local translation and spatial memory.

Science signaling·2026
Same author

Nucleolin perturbation alters membrane lipid homeostasis.

Molecular omics·2025
Same author

Repeat-element RNAs integrate a neuronal growth circuit.

Cell·2025
Same journal

An endogenous viral element of Aedes albopictus is translated and limits cognate virus.

BMC biology·2026
Same journal

Environmental sex determination in the cyst nematode Globodera pallida defaults to male development.

BMC biology·2026
Same journal

Marine mammals as models for charting the evolution of social vocal rhythm.

BMC biology·2026
Same journal

Associations between immunosenescence and domain-specific cognition in the Health and Retirement Study Harmonized Cognitive Assessment Protocol.

BMC biology·2026
Same journal

Experimental evidence for behavioural cooling as a response to virus infection in an ectothermic vertebrate.

BMC biology·2026
Same journal

DNA damage at an early developmental stage affects neurodevelopment in sterlet (Acipenser ruthenus).

BMC biology·2026
See all related articles

Related Experiment Video

Updated: Jan 25, 2026

Generation of Three-Dimensional Spheroids/Organoids from Two-Dimensional Cell Cultures Using a Novel Stamp Device
05:40

Generation of Three-Dimensional Spheroids/Organoids from Two-Dimensional Cell Cultures Using a Novel Stamp Device

Published on: March 28, 2025

1.2K

Cell size sensing-a one-dimensional solution for a three-dimensional problem?

Ida Rishal1, Mike Fainzilber2

  • 1Department of Biomolecular Sciences, Weizmann Institute of Science, 76100, Rehovot, Israel.

BMC Biology
|May 1, 2019
PubMed
Summary
This summary is machine-generated.

Animal cells sense their size using a dynamic mechanism that combines spatial and titration sensing. This process involves microtubule motors localizing RNA and regulating protein synthesis to control cell growth.

More Related Videos

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
09:37

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

12.2K
Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

24.3K

Related Experiment Videos

Last Updated: Jan 25, 2026

Generation of Three-Dimensional Spheroids/Organoids from Two-Dimensional Cell Cultures Using a Novel Stamp Device
05:40

Generation of Three-Dimensional Spheroids/Organoids from Two-Dimensional Cell Cultures Using a Novel Stamp Device

Published on: March 28, 2025

1.2K
Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation
09:37

Microfabrication of Chip-sized Scaffolds for Three-dimensional Cell cultivation

Published on: May 12, 2008

12.2K
Analysis of Cell Migration within a Three-dimensional Collagen Matrix
08:02

Analysis of Cell Migration within a Three-dimensional Collagen Matrix

Published on: October 5, 2014

24.3K

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biophysics

Background:

  • Cell size is a fundamental property with implications for cellular functions.
  • Existing models propose spatial or titration-based mechanisms for cell size sensing.
  • Coordination of cellular processes like transcription, translation, and metabolism with cell growth is crucial.

Purpose of the Study:

  • To propose a novel, dynamic model for cell size sensing in animal cells.
  • To integrate spatial and titration-based sensing mechanisms.
  • To elucidate the role of microtubule motors, RNA localization, and local protein synthesis in cell growth regulation.

Main Methods:

  • Investigating the localization of RNA encoding importin β1 and mTOR using microtubule motors.
  • Analyzing the impact of regulated local protein synthesis on cytoskeleton dynamics.
  • Developing a model that combines spatial and titration-based elements for size sensing.

Main Results:

  • Demonstrated that microtubule motor-dependent localization of specific RNAs is key to size sensing.
  • Showed that regulated local protein synthesis contributes to the dynamic size-sensing mechanism.
  • Proposed a model where cytoskeleton length sensing is linked to cell growth regulation.

Conclusions:

  • Cell size sensing in animal cells is a dynamic process integrating spatial and titration mechanisms.
  • Microtubule motor-driven RNA localization and local protein synthesis are critical components of this system.
  • This mechanism enables effective regulation of cell growth in response to cell size.