Related Experiment Video
Updated: Jan 25, 2026
05:25
Tobacco Hornworm as an Insect Model System for Cannabinoid Pre-clinical Studies
Published on: December 29, 2021
2.9K
Cannabinoids in Pain Treatment: An Overview
Theresa Mallick-Searle1, Barbara St Marie2
1Stanford Health Care, Division Pain Medicine Redwood City, California, USA.
Summary
This review clarifies medical marijuana's role in pain management, examining the endocannabinoid system and cannabinoid pharmacology. It offers guidance for nurses integrating evidence, practice, and policy.
Area of Science:
- Pharmacology
- Pain Management
- Neuroscience
Background:
- Conflicting reports on medical marijuana create misinformation.
- Healthcare providers often lack understanding of cannabinoids.
- Cannabinoids interact with the endocannabinoid system.
Purpose of the Study:
- Provide a dispassionate overview of medical marijuana.
- Focus on clinical applications in pain management.
- Review current research on marijuana for pain treatment.
Main Methods:
- Examination of the endocannabinoid system's mechanisms.
- Review of cannabinoid pharmacology.
- Synthesis of current research on marijuana and pain.
Main Results:
- The endocannabinoid system plays a role in pain modulation.
- Cannabinoids exhibit complex pharmacological effects.
- Research on marijuana for pain is evolving.
Conclusions:
- Clarify the current understanding of medical marijuana for pain.
- Recommendations for integrating research, clinical practice, and policy.
- Address the knowledge gap among healthcare providers regarding cannabinoids.
Related Concept Videos
01:20Myasthenia Gravis: Overview and Treatment
2.9K
Myasthenia gravis is a neuromuscular transmission disorder characterized by weakness and increased fatigability of skeletal muscles. It is an autoimmune disease affecting approximately one in 2000 people, where antibodies against the α1 subunit of nicotinic acetylcholine receptors are produced.
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
These antibodies interfere with the function of the nicotinic receptors in three ways: by binding to the receptor and disrupting acetylcholine binding; by causing cross-linking of receptors which...
2.9K
01:24CNS Stimulants: Cocaine, Amphetamines and Cannabinoids
819
CNS stimulants, such as cocaine, amphetamines, and cannabinoids, have varying structures and mechanisms of action that lead to different therapeutic effects and side effects. Cocaine, with its molecular formula C17H21NO4, is a tropane alkaloid and a tertiary amino compound. It has two chemical forms: the hydrochloride salt and the "freebase." The former is in powder form, while the latter involves removing the hydrochloride salt to create a form that can be smoked. Cocaine exerts its...
819
01:21Chemotherapy-Induced Nausea and Vomiting: Cannabinoids
719
Tetrahydrocannabinol (THC) is a phytocannabinoid that primarily interacts with the CB1 receptor, a type of G protein-coupled receptor (GPCR) predominantly in and around the chemoreceptor trigger zone (CTZ) and emetic center. THC also blocks the serotonin receptor activity in the dorsal vagal complex (DVC) by inhibiting serotonin release. THC exerts its anti-emetic effects through these interactions, which are beneficial for patients undergoing chemotherapy.
Two synthetic agonists of THC,...
Two synthetic agonists of THC,...
719
01:20Pain
1.3K
Pain serves as a critical warning signal that alerts the body to potential or actual harm. When mechanical pressure on the skin is intense, such as from a sharp pinch, the sensation transitions from touch to pain. Similarly, extreme temperatures, like a hot pot handle, convert the sensation of heat into pain. Pain can also result from overstimulation of other senses, such as blinding light, loud noise, or the intense heat from habañero peppers. This ability to sense pain is essential for...
1.3K
01:25Analgesia and Pain Management
1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
01:31Overview of the Reproductive System
5.2K
The reproductive system generates offspring, ensuring the survival of the species. In humans, the reproductive system is complex and involves a variety of organs and hormones that work together to ensure successful reproduction.
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
The gonads, or primary reproductive organs, produce gametes and sex hormones. In males, the testes produce spermatozoa and testosterone, which is responsible for developing secondary male sex characteristics, including a deeper voice, larger muscles, facial and body...
5.2K