Related Experiment Video

Updated: Jan 25, 2026

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence
06:23

Detection of Nuclear Blebbing and DNA Leakage in Mammalian Cells by Immunofluorescence

Published on: January 17, 2025

1.2K

Hutchinson-Gilford Progeria Syndrome: Cardiovascular Pathologies and Potential Therapies

Suowen Xu1, Zheng-Gen Jin1

  • 1Aab Cardiovascular Research Institute, Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, NY 14642, USA.

Trends in Biochemical Sciences
|May 1, 2019
PubMed

Insights

Hutchinson-Gilford progeria syndrome (HGPS) accelerates aging and causes fatal cardiovascular issues. Recent research uncovers new mechanisms and potential therapies for HGPS and aging.

Area of Science:

  • Cardiovascular Science
  • Genetics
  • Aging Research

Background:

  • Hutchinson-Gilford progeria syndrome (HGPS) is a rare genetic disorder characterized by accelerated aging.
  • Cardiovascular diseases, including atherosclerosis, myocardial infarction, and stroke, are major causes of mortality in HGPS patients.

Purpose of the Study:

  • To elucidate novel mechanisms underlying cardiovascular pathologies in HGPS.
  • To identify potential therapeutic strategies for HGPS and physiological aging.

Main Methods:

  • Review of landmark studies published in 2018-2019.
  • Analysis of genetic and molecular pathways implicated in HGPS cardiovascular complications.

Main Results:

  • Identification of novel molecular mechanisms contributing to atherosclerosis and other cardiovascular issues in HGPS.
  • Emerging therapeutic targets for HGPS-related cardiovascular disease.

Conclusions:

  • Understanding HGPS cardiovascular pathology offers insights into physiological aging.
  • Potential for novel therapies to treat HGPS and age-related cardiovascular conditions.

Keywords:
Hutchinson–Gilford progeria syndromeatherosclerosisnuclear laminspharmacotherapyphysiological agingprogeria

More Related Videos

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome06:04

Author Spotlight: Assessing the Cardiovascular Profile of Patients with Metabolic Syndrome

Published on: September 27, 2024

1.4K
Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome04:49

Author Spotlight: Investigating the Mechanisms and Inducing Models of Polycystic Ovary Syndrome

Published on: July 5, 2024

1.7K

Related Concept Videos

Overview of the Cardiovascular System01:14

Overview of the Cardiovascular System

The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
Blood Vessels
Blood...
11.2K
Regulation of the Cardiovascular System01:27

Regulation of the Cardiovascular System

The regulation of the cardiovascular system allows the body to adapt to various demands and maintain homeostasis.
The regulation of the cardiovascular system involves the autonomic nervous system (ANS), baroreceptors, and chemoreceptors, ensuring that heart rate and blood pressure are appropriately modulated in response to varying physiological demands.
The ANS comprises two main divisions: the sympathetic and parasympathetic nervous systems. The sympathetic nervous system enhances...
3.9K
Gene Therapy00:59

Gene Therapy

Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.4K
Potential Energy00:52

Potential Energy

The energy stored by a structure and location of matter in space is called potential energy. For instance, raising a kettlebell changes its spatial location and increases its potential energy. Similarly, a stretched rubber band contains potential energy which, under certain conditions, can be converted into other forms of energy, such as kinetic energy.
Chemical bonds that form attractive forces between atoms also contain potential energy, called chemical energy. When a chemical reaction...
42.4K
Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
3.9K
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
436