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Seizures in Pediatric Patients With Primary Brain Tumors
Viviane Robert-Boire1, Béatrice Desnous1, Anne Lortie1
1Division of Child Neurology, Department of Pediatrics, Montreal, Québec, Canada.
Pediatric Neurology
|May 1, 2019
Summary
Pediatric brain tumors frequently cause seizures. This study identified cortical location, tumor recurrence, and age as seizure risk factors in children, with most achieving seizure freedom after treatment.
Area of Science:
- Pediatric Neurology
- Neuro-oncology
- Epileptology
Background:
- Seizures are a common symptom in children diagnosed with primary central nervous system tumors.
- Understanding seizure characteristics and risk factors is crucial for effective management.
Purpose of the Study:
- To define seizures associated with primary central nervous system tumors in pediatric patients.
- To identify predictive risk factors for seizure occurrence and recurrence in this population.
Main Methods:
- Retrospective review of 348 pediatric patients diagnosed between January 1, 2004, and January 1, 2018.
- Data collected included demographics, tumor characteristics, seizure history, treatment, and outcomes.
- Binomial logistic regression analysis was used to determine seizure risk factors.
Main Results:
- 70 children (20.1%) experienced seizures, with cortical tumors being most common (64.3%).
- Cortical location, tumor recurrence, and age at diagnosis were significant risk factors for seizures.
- Patients with gross total resection were more likely to be weaned off antiepileptic drugs (69.6% vs. 27.3%).
Conclusions:
- This study represents the largest cohort examining tumor-related seizures in children.
- Findings offer new insights into seizure risk based on tumor types and treatment evolution.
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