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Microvascular cerebral blood flow fluctuations in association with apneas and hypopneas in acute ischemic stroke

Clara Gregori-Pla1, Raquel Delgado-Mederos2, Gianluca Cotta1

  • 1ICFO-Institut de Ciències Fotòniques, The Barcelona Institute of Science and Technology, Castelldefels (Barcelona), Spain.

Neurophotonics
|May 1, 2019
PubMed

Insights

Breathing disruptions like apnea in acute ischemic stroke patients correlate with cerebral blood flow fluctuations. This pilot study suggests altered breathing patterns may negatively impact stroke recovery.

Area of Science:

  • Neurology
  • Cardiovascular Science
  • Respiratory Medicine

Background:

  • Periodic fluctuations in microvascular cerebral blood flow (CBF) have been observed in acute ischemic stroke (AIS) patients.
  • Limited information exists on how breathing disorders affect cerebral hemodynamics post-stroke.

Purpose of the Study:

  • To investigate the link between apneic/hypopneic events and cerebral blood flow (CBF) fluctuations in AIS patients.
  • To determine if altered respiratory patterns impact cerebral hemodynamics following stroke.

Main Methods:

  • A pilot study involving 28 AIS patients screened within the first week post-stroke.
  • Utilized pulse oximetry to identify fluctuations in arterial blood oxygen saturation (SpO2).
  • Employed bilateral near-infrared diffuse correlation spectroscopy (DCS) to measure frontal lobe CBF alongside respiratory polygraphy.

Main Results:

  • Five patients (18%) exhibited SpO2 fluctuations and were included.
  • Observed biphasic CBF fluctuations, with bilateral increases and decreases in ipsilesional and contralesional hemispheres.
  • Respiratory polygraphy indicated these CBF fluctuations were generally associated with apneic and hypopneic events.

Conclusions:

  • Apneic and hypopneic events are associated with significant cerebral blood flow fluctuations in AIS patients.
  • Further research is warranted to explore the detrimental impact of altered respiratory patterns on cerebral hemodynamics in AIS.
  • Findings highlight the importance of monitoring respiratory function in stroke patients.
Keywords:
diffuse correlation spectroscopydiffuse opticssleep disordersstroke

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