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Updated: Jan 25, 2026

Visualization of Thalamocortical Axon Branching and Synapse Formation in Organotypic Cocultures
Published on: March 28, 2018
Intrinsic and extrinsic mechanisms of synapse formation and specificity in C. elegans
Ardalan Hendi1, Mizuki Kurashina1, Kota Mizumoto2
1Department of Zoology, The University of British Columbia, 2406-2350 Health Sciences Mall, Vancouver, BC, V6T 1Z3, Canada.
Abstract:
Precise neuronal wiring is critical for the function of the nervous system and is ultimately determined at the level of individual synapses. Neurons integrate various intrinsic and extrinsic cues to form synapses onto their correct targets in a stereotyped manner. In the past decades, the nervous system of nematode (Caenorhabditis elegans) has provided the genetic platform to reveal the genetic and molecular mechanisms of synapse formation and specificity. In this review, we will summarize the recent discoveries in synapse formation and specificity in C. elegans.
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