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JenaTron - An Experimental Approach to Study the Effects of Plant History and Soil History on Grassland Ecosystem Functioning
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Naming, History, Future.

Akira Kudo1,2

  • 1International Frontier, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan. akudo@bio.titech.ac.jp.

Advances in Experimental Medicine and Biology
|May 1, 2019
PubMed
Summary

Periostin, a matricellular protein, plays a role in fibrillogenesis, the process of fiber formation. Its involvement in incurable diseases highlights its significance in medical research.

Keywords:
FibrillogenesisIncurable diseasePeriodontal ligamentPeriosteumPeriostin

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Pathology

Background:

  • Periostin is a matricellular protein involved in extracellular matrix remodeling.
  • Understanding periostin's function is crucial for developing treatments for various diseases.

Purpose of the Study:

  • To elucidate the historical context of periostin research.
  • To describe the molecular mechanisms of periostin in fibrillogenesis.
  • To highlight periostin's association with incurable diseases.

Main Methods:

  • Literature review of historical periostin studies.
  • Analysis of molecular pathways involved in fibrillogenesis.
  • Review of clinical data linking periostin to disease progression.

Main Results:

  • Periostin's role in collagen organization and matrix assembly was detailed.
  • The protein's involvement in fibrotic processes was established.
  • Specific incurable diseases associated with altered periostin levels were identified.

Conclusions:

  • Periostin is a key regulator of fibrillogenesis with significant implications in disease.
  • Further research into periostin mechanisms may lead to novel therapeutic strategies.