Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Regulation of Stroke Volume01:27

Regulation of Stroke Volume

4.8K
The regulation of stroke volume, which is the amount of blood the heart pumps out during each heartbeat, is critical for maintaining a healthy circulatory system. Stroke volume is influenced by three main factors: preload, contractility, and afterload.
Preload refers to the degree of stretch on the heart before it contracts. It's analogous to the stretching of a rubber band; the more it's stretched, the more forcefully it snaps back. This concept is encapsulated in the Frank-Starling law of the...
4.8K
Liver Histology01:27

Liver Histology

4.2K
The microscopic anatomy of the liver is a complex and intricate system that comprises numerous structural units known as liver lobules, each of which is comparable in size to a sesame seed. These hexagonal structures consist of plates of liver cells or hepatocytes, which are characterized by their versatility and abundance of cellular apparatus like rough and smooth ER, Golgi apparatus, peroxisomes, and mitochondria.
Hepatocytes perform a variety of essential functions. They secrete...
4.2K
Liver Physiology01:30

Liver Physiology

3.6K
The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
The liver is the central organ involved in regulating blood composition. It stabilizes blood glucose levels, maintaining them within the range of  70–110 mg/dL. When these levels drop, the liver breaks down glycogen reserves and releases glucose into the bloodstream. It can...
3.6K
Liver Regeneration01:24

Liver Regeneration

4.3K
The liver is an important organ in vertebrates that plays an essential role in metabolism. It is also responsible for storing and redistributing nutrients such as carbohydrates, fats, and vitamins in the body. Additionally, the liver releases bile salts which are critical for digesting food and eliminating toxic metabolites from the body.
Cells of Liver
The liver comprises four major types of cells— hepatocytes, stellate, Kupffer, and sinusoidal endothelial cells. The hepatocytes are...
4.3K
Cardiac Output and Stroke Volume01:11

Cardiac Output and Stroke Volume

4.6K
Cardiac output (CO) is an integral aspect of human physiology, reflecting the heart's efficiency and responsiveness to the body's needs. It represents the volume of blood that the left or right ventricle ejects into the aorta or pulmonary trunk each minute. The CO is calculated by multiplying the heart rate (HR)—the number of heartbeats per minute—by the stroke volume (SV)—the amount of blood pumped out with each heartbeat.
In an average resting adult male, the typical cardiac...
4.6K
Gross Anatomy of the Liver01:17

Gross Anatomy of the Liver

2.0K
The liver, the largest gland within the human body, is a firm and reddish-brown organ. This wedge-shaped structure weighs approximately 1.5 kg and occupies a significant portion of the right hypochondriac and epigastric regions. It extends more to the right of the body's midline than to the left.
Located under the diaphragm, the liver is almost entirely ensconced within the rib cage, providing it with substantial protection. Except for the superior most bare area, the liver's surface is...
2.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Detecting Distant Metastases in Prostate Cancer Using Whole-body MR Imaging Together with DWIBS (Diffusion-weighted Imaging with Background Body Signal Suppression).

Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine·2026
Same author

Ni-doped 3D-printed honeycomb carbon microlattices: Sustainable fabrication and functionalization of microarchitected carbon.

iScience·2025
Same author

Tuning Electrocatalytic Activities of Dealloyed Nanoporous Catalysts by Macroscopic Strain Engineering.

Nano letters·2024
Same author

Measurement of solid size in early-stage lung adenocarcinoma by virtual 3D thin-section CT applied artificial intelligence.

Scientific reports·2023
Same author

Stereolithography 3D Printed Carbon Microlattices with Hierarchical Porosity for Structural and Functional Applications.

Small (Weinheim an der Bergstrasse, Germany)·2023
Same author

Ultrafine nanoporous intermetallic catalysts by high-temperature liquid metal dealloying for electrochemical hydrogen production.

Nature communications·2022

Related Experiment Video

Updated: Jan 25, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

1.5K

Liver, Stroke, Rhinosinusitis.

Akira Kudo1,2

  • 1International Frontier, Tokyo Institute of Technology, Meguro-ku, Tokyo, Japan. akudo@bio.titech.ac.jp.

Advances in Experimental Medicine and Biology
|May 1, 2019
PubMed
Summary

Periostin is implicated in new fibrosis cases like liver fibrosis, stroke, and rhinosinusitis. Understanding its role in inflammation-linked fibrosis can help uncover mechanisms of unknown diseases.

Keywords:
Liver fibrosisMuscular dystrophyRhinosinusitisStrokeUterine fibroid

More Related Videos

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
06:07

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

7.6K
In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
12:35

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

19.6K

Related Experiment Videos

Last Updated: Jan 25, 2026

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies
10:45

The Mouse Stroke Unit Protocol with Standardized Neurological Scoring for Translational Mouse Stroke Studies

Published on: February 7, 2025

1.5K
Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis
06:07

Modeling Stroke in Mice: Focal Cortical Lesions by Photothrombosis

Published on: May 6, 2021

7.6K
In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion
12:35

In vivo Liver Endocytosis Followed by Purification of Liver Cells by Liver Perfusion

Published on: November 10, 2011

19.6K

Area of Science:

  • Fibrosis research
  • Inflammation biology
  • Disease mechanisms

Background:

  • Fibrosis, a hallmark of many diseases, is increasingly recognized in diverse conditions.
  • Periostin, a matricellular protein, has known roles in fibrosis.
  • Emerging evidence links periostin to novel fibrotic conditions.

Purpose of the Study:

  • To explore the role of periostin in newly identified fibrotic diseases.
  • To investigate periostin's function in inflammation-associated fibrosis.
  • To establish periostin as a tool for understanding obscure fibrotic diseases.

Main Methods:

  • Literature review of periostin's involvement in fibrosis.
  • Analysis of case studies reporting periostin in liver fibrosis, stroke, and rhinosinusitis.
  • Conceptual framework for periostin's mechanistic role in inflammation.

Main Results:

  • Periostin is newly associated with liver fibrosis, stroke, and rhinosinusitis.
  • These conditions represent novel areas of periostin action.
  • Periostin's function is linked to inflammation in these contexts.

Conclusions:

  • Periostin plays a role in diverse fibrotic diseases beyond established types.
  • Investigating periostin offers insights into inflammation-driven fibrosis.
  • Periostin can serve as a valuable biomarker and research tool for unknown fibrotic diseases.