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A Data-Driven Approach to Quantifying Immune States in Sepsis
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Maternal sepsis is an evolving challenge.

Michael J Turner1

  • 1UCD Centre for Human Reproduction, Coombe Women and Infants University Hospital, Dublin, Ireland.

International Journal of Gynaecology and Obstetrics: the Official Organ of the International Federation of Gynaecology and Obstetrics
|May 1, 2019
PubMed
Summary
This summary is machine-generated.

Maternal sepsis, a leading cause of maternal death, lacks a clear definition. The World Health Organization (WHO) has proposed a new clinical definition to improve diagnosis and management of this global health issue.

Keywords:
Early neonatal sepsisMaternal infectionMaternal infection complicationsMaternal morbidityMaternal mortalityMaternal sepsisMaternal sepsis criteriaObstetric early warning scores

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Area of Science:

  • Obstetrics and Gynecology
  • Infectious Diseases
  • Public Health

Background:

  • Maternal sepsis is a significant cause of preventable maternal mortality worldwide.
  • Lack of a standardized definition hinders progress in managing maternal sepsis.
  • Previous consensus focused on non-pregnant adults and pregnant women separately.

Purpose of the Study:

  • To address the lack of consensus on maternal sepsis definition.
  • To introduce the World Health Organization's (WHO) 2017 definition of maternal sepsis.
  • To highlight the need for standardized diagnostic criteria for early identification and management.

Main Methods:

  • Reviewed evidence from multidisciplinary consensus conferences.
  • Incorporated findings on clinical, bedside-applicable diagnostic criteria.
  • Utilized the WHO's 2017 definition based on suspected or confirmed infection.

Main Results:

  • The WHO published a new definition of maternal sepsis in 2017.
  • A Global Maternal and Neonatal Sepsis Initiative was launched.
  • Standardized criteria are expected to optimize clinical audit and research.

Conclusions:

  • A clear, clinically-based definition is crucial for maternal sepsis diagnosis.
  • Standardization will facilitate earlier recognition and management of maternal infection.
  • Further international consensus is needed on criteria for maternal sepsis and organ dysfunction.