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Updated: Jan 25, 2026

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models
09:58

Using RNA-sequencing to Detect Novel Splice Variants Related to Drug Resistance in In Vitro Cancer Models

Published on: December 9, 2016

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Cancer drug resistance: A fleet to conquer

Showket Hussain1, Ankita Singh1, Sheeraz Un Nazir1

  • 1Division of Cellular and Molecular Diagnostics, National Institute of Cancer Prevention and Research, Noida, India.

Journal of Cellular Biochemistry
|May 1, 2019
PubMed

Insights

Cancer drug resistance is a major challenge, often caused by genetic factors and the tumor environment. Understanding these causes is key to developing more effective cancer treatments and improving patient outcomes worldwide.

Area of Science:

  • Oncology
  • Molecular Biology
  • Pharmacology

Background:

  • Cancer remains a leading cause of global mortality.
  • Current cancer therapeutics frequently encounter treatment failure due to drug resistance.
  • Identifying the mechanisms of drug resistance is crucial for advancing cancer care.

Purpose of the Study:

  • To review and consolidate known factors contributing to cancer drug resistance.
  • To provide researchers with comprehensive information on resistance mechanisms.
  • To aid in the development of novel and effective cancer therapeutics.

Main Methods:

  • Literature review of scientific publications.
  • Compilation of reported factors influencing cancer drug resistance.
  • Analysis of genetic and non-genetic resistance mechanisms.

Main Results:

  • Cancer drug resistance is multifactorial, involving genetic heterogeneity (e.g., gene mutations).
  • Key contributors include the tumor microenvironment, exosomes, and microRNAs (miRNAs).
  • High rates of drug efflux from cancer cells also play a significant role.

Conclusions:

  • A thorough understanding of cancer drug resistance factors is essential.
  • This knowledge can guide the development of next-generation cancer therapies.
  • Improved therapeutics will enhance the management of various cancer types globally.
Keywords:
alternate signaling pathwaycancer drug resistanceexosomesmiRNAstumor microenvironment

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