Predictors of complication after adrenalectomy

Area of Science:

• Endocrinology
• Surgical Oncology
• Adrenal Gland Disorders

Background:

• Adrenalectomy is a surgical procedure to remove the adrenal gland.
• Identifying risk factors for complications is crucial for patient safety and outcomes.

Purpose of the Study:

• To investigate risk factors associated with intra-operative and post-operative complications in patients undergoing adrenalectomy.
• To identify independent predictors of morbidity and mortality following adrenalectomy.

Main Methods:

• Retrospective analysis of 154 patients who underwent adrenalectomy between 2014 and 2018.
• Correlation of clinical parameters and adrenal disorder characteristics with operative course.
• Logistic regression analysis to determine independent predictors of complications and death.

Main Results:

• Post-operative complications occurred in 17.5% (minor) and 8.4% (major) of patients. Intra-operative complications occurred in 26.6% of patients.
• Patient age, comorbidities, and pathological diagnosis were independent predictors of post-operative complications.
• Tumor size and Body Mass Index (BMI) predicted intra-operative complications, while pathological diagnosis and Charlson score predicted death.

Conclusions:

• Older patients with multiple comorbidities and unfavorable adrenal disorders (adrenocortical carcinoma, pheochromocytoma) are at higher risk for post-operative complications.
• Elevated BMI and larger tumors are associated with increased risk of intra-operative complications, but not post-operative ones.