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Schimke immunoosseous dysplasia and management considerations for vascular risks
Daniah T Beleford1, Mohammad Diab2, William F Qubty3
1Division of Medical Genetics, Department of Pediatrics, Institute for Human Genetics, University of California San Francisco, San Francisco, California.
Schimke immunoosseous dysplasia (SIOD) management improved with tighter blood pressure control, reducing headaches. This study also characterizes dyslipidemia and suggests new strategies for SIOD patient care.
Area of Science:
- Genetics and Rare Diseases
- Nephrology
- Neurology
- Cardiology
Background:
- Schimke immunoosseous dysplasia (SIOD) is a rare multisystemic disorder.
- Key features include early arteriosclerosis, renal insufficiency, and neurological issues like headaches and ischemic events.
- The relationship between hypertension, dyslipidemia, and cardiovascular risk in SIOD is not well understood.
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